The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Microneedles for drug and vaccine delivery
Open accessAbstract
Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990’s when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that encapsulate drug and fully dissolve in the skin and (iv) hollow microneedles for drug infusion into the skin. As shown in more than 350 papers now published in the field, microneedles have been used to deliver a broad range of different low molecular weight drugs, biotherapeutics and vaccines, including published human studies with a number of small-molecule and protein drugs and vaccines. Influenza vaccination using a hollow microneedle is in widespread clinical use and a number of solid microneedle products are sold for cosmetic purposes. In addition to applications in the skin, microneedles have also been adapted for delivery of bioactives into the eye and into cells. Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug efficacy and safety. Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.
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Cites
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Self-citationChronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex
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Silicon micromachined hollow microneedles for transdermal liquid transport
Gardeniers, H. J. G. E., Luttge, R., Berenschot, E. J. W., de Boer, M. J., Yeshurun, S. Y., Hefetz, M., van-t Oever, R., & van den Berg, A. (2003) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2003.820293 · Cited by 413
Suprachoroidal drug delivery to the back of the eye using hollow microneedles
Patel, S. R., Lin, A. S. P., Edelhauser, H. F., & Prausnitz, M. R. (2011) · Pharmaceutical Research · doi:10.1007/s11095-010-0271-y · Cited by 330
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Past, Present, and Future Technologies for Oral Delivery of Therapeutic Proteins
Singh, R., Singh, S., & Lillard, J. W. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21183 · Cited by 186 · cited 1×
“Oral delivery largely overcomes these problems, but many drugs cannot be given by this route due to poor absorption and drug degradation in the gastrointestinal tract and liver [6].”
Background
Cited by
Larrañeta, E., Lutton, R. E. M., Woolfson, A. D., & Donnelly, R. F. (2016) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2016.03.001 · Cited by 964
Accessing analytes in biofluids for peripheral biochemical monitoring
Heikenfeld, J., Jajack, A., Feldman, B., Granger, S. W., Gaitonde, S., Begtrup, G., & Katchman, B. A. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0040-3 · Cited by 758
Yin, M., Wu, J., Deng, M., Wang, P., Ji, G., Wang, M., Zhou, C., Blum, N. T., Zhang, W., Shi, H., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c06036 · Cited by 380
Advances in transdermal insulin delivery
Zhang, Y., Yu, J., Kahkoska, A. R., Wang, J., Buse, J. B., & Gu, Z. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.006 · Cited by 325
Microneedling: Advances and widening horizons
Yadav, S., & Singh, A. (2016) · Indian Dermatology Online Journal · doi:10.4103/2229-5178.185468 · Cited by 321
Metadata
- Authors
- Kim, Y.-C., Park, J.-H., & Prausnitz, M. R.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 64
- Issue
- 14
- Pages
- 1547-1568
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2007539416
- Cited by
- 1,760
- References
- 9
- FWCI
- 10.58
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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