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Quantum Dots with a Paramagnetic Coating as a Bimodal Molecular Imaging Probe
Open accessAbstract
MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r(1), of nearly 2000 mM(-1)s(-1) per quantum dot. The quantum dots were functionalized by covalently linking alphavbeta3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes.
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Citations
Cites
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Cited by
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Multimodality Imaging Probes: Design and Challenges
Louie, A. (2010) · Chemical Reviews · doi:10.1021/cr9003538 · Cited by 1,044
Nanotechnology applications in cancer
Nie, S., Xing, Y., Kim, G. J., & Simons, J. W. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.152025 · Cited by 952
‘Two is better than one’—probes for dual-modality molecular imaging
Jennings, L. E., & Long, N. J. (2009) · Chemical Communications · doi:10.1039/b821903f · Cited by 438
Dual-Function Probe for PET and Near-Infrared Fluorescence Imaging of Tumor Vasculature
Cai, W., Chen, K., Li, Z.-B., Gambhir, S. S., & Chen, X. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.043216 · Cited by 429
Metadata
- Authors
- Mulder, W. J. M., Koole, R., Brandwijk, R. J., Storm, G., Chin, P. T. K., Strijkers, G. J., de Mello Donegá, C., Nicolay, K., & Griffioen, A. W.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-11-24
- Volume
- 6
- Issue
- 1
- Pages
- 1-6
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2116927089
- Cited by
- 482
- References
- 1
- FWCI
- 23.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Mulder, W. J. M., Koole, R., Brandwijk, R. J., Storm, G., Chin, P. T. K., Strijkers, G. J., de Mello Donegá, C., Nicolay, K., & Griffioen, A. W. (2006). Quantum Dots with a Paramagnetic Coating as a Bimodal Molecular Imaging Probe. Nano Letters. https://doi.org/10.1021/nl051935m
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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