The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Importance of an Endotoxin-Free Environment during the Production of Nanoparticles Used in Medical Applications
Abstract
We investigated the effect of spherical gold nanoparticles on immature dendritic cells (DCs). Conventionally produced nanoparticles had a maturating effect on the DCs--a result of lipopolysaccharide (LPS) contamination. By modification of the production process, low-LPS particles were obtained, which had practically no effect on phenotypic maturation or cytokine production of the DCs. Our findings emphasize the importance of high purity in the production of nanoparticles, since possible contaminants may interfere with the assessment of biological/medical effects. They also highlight that nanoparticles can function as carriers of immune modulating contaminants.
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Citations
Cites
Seventeen-colour flow cytometry: unravelling the immune system
Perfetto, S. P., Chattopadhyay, P. K., & Roederer, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1416 · Cited by 1,019
Cited by
Immunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
Minireview: Nanoparticles and the Immune System
Zolnik, B. S., González-Fernández, A., Sadrieh, N., & Dobrovolskaia, M. A. (2010) · Endocrinology · doi:10.1210/en.2009-1082 · Cited by 914
In vitro assessments of nanomaterial toxicity
Jones, C. F., & Grainger, D. W. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.005 · Cited by 554
Sapsford, K. E., Tyner, K. M., Dair, B. J., Deschamps, J. R., & Medintz, I. L. (2011) · Analytical Chemistry · doi:10.1021/ac200853a · Cited by 538
Kunzmann, A., Andersson, B., Thurnherr, T., Krug, H., Scheynius, A., & Fadeel, B. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.04.007 · Cited by 527
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Metadata
- Authors
- Vallhov, H., Qin, J., Johansson, S. M., Ahlborg, N., Muhammed, M. A., Scheynius, A., & Gabrielsson, S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-07-22
- Volume
- 6
- Issue
- 8
- Pages
- 1682-1686
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1968012969
- Cited by
- 238
- References
- 1
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vallhov, H., Qin, J., Johansson, S. M., Ahlborg, N., Muhammed, M. A., Scheynius, A., & Gabrielsson, S. (2006). The Importance of an Endotoxin-Free Environment during the Production of Nanoparticles Used in Medical Applications. Nano Letters. https://doi.org/10.1021/nl060860z
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
