Minireview: Nanoparticles and the Immune System
Open accessAbstract
Today nanotechnology is finding growing applications in industry, biology, and medicine. The clear benefits of using nanosized products in various biological and medical applications are often challenged by concerns about the lack of adequate data regarding their toxicity. One area of interest involves the interactions between nanoparticles and the components of the immune system. Nanoparticles can be engineered to either avoid immune system recognition or specifically inhibit or enhance the immune responses. We review herein reported observations on nanoparticle-mediated immunostimulation and immunosuppression, focusing on possible theories regarding how manipulation of particle physicochemical properties can influence their interaction with immune cells to attain desirable immunomodulation and avoid undesirable immunotoxicity.
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Properties such as size, surface charge, hydrophobicity/hydrophilicity, and steric effects of particle coating influence compatibility of nanoparticles with immune system.
“Additionally, the properties such as size, surface charge, hydrophobicity/hydrophilicity, and the steric effects of particle coating have influence on the compatibility of nanoparticles with the immune system [147–150].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [147]
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- Authors
- Zolnik, B. S., González-Fernández, A., Sadrieh, N., & Dobrovolskaia, M. A.
- Affiliations
- United States Food and Drug Administration (US)
- Área de Inmunología and Unidad Compartida Complejo Hospitalario Universitario de Vigo (Á.G.-F.), Edificio Ciencias Experimentales, University of Vigo, Campus Lagoas Marcosende, 36310 Vigo, Pontevedra, Spain;
- Frederick National Laboratory for Cancer Research (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2010-02-01
- Volume
- 151
- Issue
- 2
- Pages
- 458-465
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC2817614
- OpenAlex
- W2000755721
- Cited by
- 914
- References
- 75
- Citations by year
- 2026: 24 · 2025: 45 · 2024: 75 · 2023: 66 · 2022: 70 · 2021: 73 · 2020: 56 · 2019: 62 · 2018: 74 · 2017: 67 · 2016: 64 · 2015: 61 · 2014: 47 · 2013: 53 · 2012: 48
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (HHSN261200800001C)
- National Cancer Institute (HHSN261200800001E))
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- nanoparticles, immune system, immunomodulation, immunostimulation, immunosuppression, immunotoxicity, nanoparticle physicochemical properties, immune cell interactions, nanomedicine
- MeSH terms
- Animals, B-Lymphocytes, Humans, Immune System, Immunization, Immunosuppression Therapy, Infections, Liposomes, Lymphocyte Activation, Neoplasms, Polyethylene Glycols, T-Lymphocytes, Nanotechnology, Nanoparticles
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