The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Organically Modified Silica Nanoparticles with Covalently Incorporated Photosensitizer for Photodynamic Therapy of Cancer
Abstract
We report a novel nanoformulation of a photosensitizer (PS), for photodynamic therapy (PDT) of cancer, where the PS molecules are covalently incorporated into organically modified silica (ORMOSIL) nanoparticles. We found that the covalently incorporated PS molecules retained their spectroscopic and functional properties and could robustly generate cytotoxic singlet oxygen molecules upon photoirradiation. The synthesized nanoparticles are of ultralow size ( approximately 20 nm) and are highly monodispersed and stable in aqueous suspension. The advantage offered by this covalently linked nanofabrication is that the drug is not released during systemic circulation, which is often a problem with physical encapsulation. These nanoparticles are also avidly uptaken by tumor cells in vitro and demonstrate phototoxic action, thereby highlighting their potential in diagnosis and PDT of cancer.
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Self-citationState of the art in the delivery of photosensitizers for photodynamic therapy
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Self-citationBharali, D. J., Lucey, D. W., Jayakumar, H., Pudavar, H. E., & Prasad, P. N. (2005) · Journal of the American Chemical Society · doi:10.1021/ja051455x · Cited by 473
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Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Nanoparticles as vehicles for delivery of photodynamic therapy agents
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Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials
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Nano drug delivery strategy of 5-fluorouracil for the treatment of colorectal cancer
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Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy
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Metadata
- Authors
- Ohulchanskyy, T. Y., Roy, I., Goswami, L. N., Chen, Y., Bergey, E. J., Pandey, R. K., Oseroff, A. R., & Prasad, P. N.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-08-25
- Volume
- 7
- Issue
- 9
- Pages
- 2835-2842
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2012748063
- Cited by
- 329
- References
- 19
- FWCI
- 17.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ohulchanskyy, T. Y., Roy, I., Goswami, L. N., Chen, Y., Bergey, E. J., Pandey, R. K., Oseroff, A. R., & Prasad, P. N. (2007). Organically Modified Silica Nanoparticles with Covalently Incorporated Photosensitizer for Photodynamic Therapy of Cancer. Nano Letters. https://doi.org/10.1021/nl0714637
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