The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Organically Modified Silica Nanoparticles with Covalently Incorporated Photosensitizer for Photodynamic Therapy of Cancer
Abstract
We report a novel nanoformulation of a photosensitizer (PS), for photodynamic therapy (PDT) of cancer, where the PS molecules are covalently incorporated into organically modified silica (ORMOSIL) nanoparticles. We found that the covalently incorporated PS molecules retained their spectroscopic and functional properties and could robustly generate cytotoxic singlet oxygen molecules upon photoirradiation. The synthesized nanoparticles are of ultralow size ( approximately 20 nm) and are highly monodispersed and stable in aqueous suspension. The advantage offered by this covalently linked nanofabrication is that the drug is not released during systemic circulation, which is often a problem with physical encapsulation. These nanoparticles are also avidly uptaken by tumor cells in vitro and demonstrate phototoxic action, thereby highlighting their potential in diagnosis and PDT of cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565
Roy, I., Ohulchanskyy, T. Y., Pudavar, H. E., Bergey, E. J., Oseroff, A. R., Morgan, J., Dougherty, T. J., & Prasad, P. N. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0343095 · Cited by 929
Self-citationState of the art in the delivery of photosensitizers for photodynamic therapy
Konan, Y. N., Gurny, R., & Allémann, E. (2002) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00267-6 · Cited by 906
PHOTOSENSITIZERS: THERAPY AND DETECTION OF MALIGNANT TUMORS
Dougherty, T. J. (1987) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1987.tb07898.x · Cited by 776
Kim, S., Ohulchanskyy, T. Y., Pudavar, H. E., Pandey, R. K., & Prasad, P. N. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0680257 · Cited by 689
Self-citationBharali, D. J., Lucey, D. W., Jayakumar, H., Pudavar, H. E., & Prasad, P. N. (2005) · Journal of the American Chemical Society · doi:10.1021/ja051455x · Cited by 473
Self-citationRoy, I., Ohulchanskyy, T. Y., Bharali, D. J., Pudavar, H. E., Mistretta, R. A., Kaur, N., & Prasad, P. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408039101 · Cited by 457
Self-citationPrasad, P. N., & Masters, B. R. (2005) · Journal of Biomedical Optics · doi:10.1117/1.1931672 · Cited by 441
Self-citationNanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy
Wang, S., Gao, R., Zhou, F., & Selke, M. (2004) · Journal of Materials Chemistry · doi:10.1039/b311429e · Cited by 384
Polymeric micelles to deliver photosensitizers for photodynamic therapy
VANNOSTRUM, C. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.07.013 · Cited by 342
Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
Chen, G., Roy, I., Yang, C., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00148 · Cited by 1,499
Self-citationCroissant, J. G., Fatieiev, Y., & Khashab, N. M. (2017) · Advanced Materials · doi:10.1002/adma.201604634 · Cited by 782
Nanoparticles as vehicles for delivery of photodynamic therapy agents
Bechet, D., Couleaud, P., Frochot, C., Viriot, M.-L., Guillemin, F., & Barberi-Heyob, M. (2008) · Trends in Biotechnology · doi:10.1016/j.tibtech.2008.07.007 · Cited by 760
Nanotechnology in Therapeutics: A Focus on Nanoparticles as A Drug Delivery System
Bamrungsap, S., Zhao, Z., Chen, T., Wang, L., Li, C., Fu, T., & Tan, W. (2012) · Nanomedicine · doi:10.2217/nnm.12.87 · Cited by 606
Fan, H., Yan, G., Zhao, Z., Hu, X., Zhang, W., Liu, H., Fu, X., Fu, T., Zhang, X., & Tan, W. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510748 · Cited by 567
Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review
Calixto, G., Bernegossi, J., De Freitas, L., Fontana, C., & Chorilli, M. (2016) · Molecules · doi:10.3390/molecules21030342 · Cited by 538
Nonporous silica nanoparticles for nanomedicine application
Tang, L., & Cheng, J. (2013) · Nano Today · doi:10.1016/j.nantod.2013.04.007 · Cited by 488
Advance in Photosensitizers and Light Delivery for Photodynamic Therapy
Yoon, I., Li, J. Z., & Shim, Y. K. (2013) · Clinical Endoscopy · doi:10.5946/ce.2013.46.1.7 · Cited by 425
Nanoscale metal–organic frameworks for phototherapy of cancer
Lan, G., Ni, K., & Lin, W. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.09.007 · Cited by 420
Nanotechnology, nanotoxicology, and neuroscience
Suh, W. H., Suslick, K. S., Stucky, G. D., & Suh, Y.-H. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.009 · Cited by 406
Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials
Hong, E. J., Choi, D. G., & Shim, M. S. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.01.007 · Cited by 361
Nanomaterials formulations for photothermal and photodynamic therapy of cancer
Shibu, E. S., Hamada, M., Murase, N., & Biju, V. (2013) · Journal of Photochemistry and Photobiology C: Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2012.09.004 · Cited by 356
Dąbrowski, J. M., Pucelik, B., Regiel-Futyra, A., Brindell, M., Mazuryk, O., Kyzioł, A., Stochel, G., Macyk, W., & Arnaut, L. G. (2016) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2016.06.007 · Cited by 317
Silica-based nanoparticles for photodynamic therapy applications
Couleaud, P., Morosini, V., Frochot, C., Richeter, S., Raehm, L., & Durand, J.-O. (2010) · Nanoscale · doi:10.1039/c0nr00096e · Cited by 278
Nanocomposite‐Based Photodynamic Therapy Strategies for Deep Tumor Treatment
Hu, J., Tang, Y., Elmenoufy, A. H., Xu, H., Cheng, Z., & Yang, X. (2015) · Small · doi:10.1002/smll.201501923 · Cited by 262
Nano drug delivery strategy of 5-fluorouracil for the treatment of colorectal cancer
Chandran, S. P., Natarajan, S. B., Chandraseharan, S., & Mohd Shahimi, M. S. B. (2017) · Journal of Cancer Research and Practice · doi:10.1016/j.jcrpr.2017.02.002 · Cited by 97
Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy
Kano, A., Taniwaki, Y., Nakamura, I., Shimada, N., Moriyama, K., & Maruyama, A. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.02.016 · Cited by 34
Metadata
- Authors
- Ohulchanskyy, T. Y., Roy, I., Goswami, L. N., Chen, Y., Bergey, E. J., Pandey, R. K., Oseroff, A. R., & Prasad, P. N.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-08-25
- Volume
- 7
- Issue
- 9
- Pages
- 2835-2842
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2012748063
- Cited by
- 329
- References
- 19
- FWCI
- 17.45
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
