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Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles
Open accessAbstract
The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.
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Citations
Cited by
The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
Albanese, A., Tang, P. S., & Chan, W. C. W. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150124 · Cited by 3,633
Applications of Nanoparticles in Biology
De, M., Ghosh, P. S., & Rotello, V. M. (2008) · Advanced Materials · doi:10.1002/adma.200703183 · Cited by 1,547
Ratiometric optical nanoprobes enable accurate molecular detection and imaging
Huang, X., Song, J., Yung, B. C., Huang, X., Xiong, Y., & Chen, X. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00612h · Cited by 820
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
Biomaterials for mRNA delivery
Islam, M. A., Reesor, E. K. G., Xu, Y., Zope, H. R., Zetter, B. R., & Shi, J. (2015) · Biomaterials Science · doi:10.1039/c5bm00198f · Cited by 176
Metadata
- Authors
- Giljohann, D. A., Seferos, D. S., Patel, P. C., Millstone, J. E., Rosi, N. L., & Mirkin, C. A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-11-13
- Volume
- 7
- Issue
- 12
- Pages
- 3818-3821
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1988190543
- Cited by
- 552
- References
- 0
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Giljohann, D. A., Seferos, D. S., Patel, P. C., Millstone, J. E., Rosi, N. L., & Mirkin, C. A. (2007). Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles. Nano Letters. https://doi.org/10.1021/nl072471q
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
