The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Role of Endosomal Escape for Disulfide-Based Drug Delivery from Colloidal Mesoporous Silica Evaluated by Live-Cell Imaging
Abstract
Redox-driven intracellular disulfide-cleavage is a promising strategy to achieve stimuli-responsive and controlled drug release. We synthesized colloidal mesoporous silica (CMS) nanoparticles with ATTO633-labeled cysteine linked to the inner particle core via disulfide-bridges and characterized their cysteine release behavior after internalization into HuH7 cells by high-resolution fluorescence microscopy. Our study revealed that endosomal escape is a bottleneck for disulfide-linkage based drug release. Photochemical opening of the endosome leads to successful delivery of fluorescently labeled cysteine to the cytosol.
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Cites
Photo-Driven Expulsion of Molecules from Mesostructured Silica Nanoparticles
Angelos, S., Choi, E., Vögtle, F., De Cola, L., & Zink, J. I. (2007) · The Journal of Physical Chemistry C · doi:10.1021/jp070721l · Cited by 227
Actin Cytoskeleton as the Principal Determinant of Size-dependent DNA Mobility in Cytoplasm
Dauty, E., & Verkman, A. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412374200 · Cited by 215
Cited by
Croissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 594
Biocompatibility of Mesoporous Silica Nanoparticles
Asefa, T., & Tao, Z. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300166u · Cited by 422
Targeted Drug Delivery in Cancer Cells with Red-Light Photoactivated Mesoporous Silica Nanoparticles
Mackowiak, S. A., Schmidt, A., Weiss, V., Argyo, C., von Schirnding, C., Bein, T., & Bräuchle, C. (2013) · Nano Letters · doi:10.1021/nl400681f · Cited by 170
Self-citationDevelopment of Mesoporous Silica Nanomaterials As a Vehicle for Anticancer Drug Delivery
Yanes, R. E., & Tamanoi, F. (2012) · Therapeutic Delivery · doi:10.4155/tde.12.9 · Cited by 68
Metadata
- Authors
- Sauer, A. M., Schlossbauer, A., Ruthardt, N., Cauda, V., Bein, T., & Bräuchle, C.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-08-02
- Volume
- 10
- Issue
- 9
- Pages
- 3684-3691
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2085234018
- Cited by
- 167
- References
- 2
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- closed
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