Cited by 68Nanoparticle-Based Drug DeliveryMesoporous Materials and CatalysisClay minerals and soil interactions

Development of Mesoporous Silica Nanomaterials As a Vehicle for Anticancer Drug Delivery

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Yanes, Rolando E, Tamanoi, Fuyuhiko·2012·Therapeutic Delivery

Abstract

The development of delivery vehicles that would carry therapeutic agents selectively to cancer cells has become an important focus in biomedical research. Nanoparticles have received much attention because the advances made in this field have resulted in multiple biocompatible materials. In particular, mesoporous silica nanoparticles (MSNs) offer a solid framework with porous structure and high surface area that allows for the attachment of different functional groups. In this article we discuss the different surface modifications made to MSNs that have allowed for the construction of targeted nanoparticles to enhance accumulation and uptake in target sites, the incorporation of nanomachines for controlled cargo release and the combination with superparamagnetic metals for MRI cell labeling. We also discuss biocompatibility, biodistribution and drug-delivery efficacy of MSNs. Finally, we mention the construction of multifunctional nanoparticles that combine all of the previously examined nanoparticle modifications.

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  • Mesoporous silica nanoparticles can have their surface altered for active targeting by adding peptides, folate, mannose, and transferrin.

    “Mesoporous silica nanoparticles can have their surface altered for active targeting by adding peptides, folate, mannose, and transferrin.75–77”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [75]

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Authors
Yanes, R. E., & Tamanoi, F.
Affiliations
California NanoSystems Institute (US)
Venue
Therapeutic Delivery
Published
2012-03
Volume
3
Issue
3
Pages
389-404
ISSN
  • 2041-5990 (ISSN-L)
  • 2041-6008
OpenAlex
W2168557738
Cited by
68
References
89
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 2 · 2015: 9 · 2014: 5 · 2013: 5 · 2012: 2
FWCI
0.35
Type
journal article
Language
en
Open access
Locations
  • Therapeutic Delivery (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (R01CA133697, CA 133697)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Materials Chemistry › Mesoporous Materials and Catalysis
  • Physical Sciences › Materials Science › Biomaterials › Clay minerals and soil interactions
Keywords
mesoporous silica nanoparticles, anticancer drug delivery, targeted drug delivery, surface modification, controlled release, superparamagnetic iron oxide nanoparticles, tissue distribution, biocompatibility, multifunctional nanoparticles, nanoparticle drug carriers
MeSH terms
Antineoplastic Agents, Exocytosis, Hydrogen-Ion Concentration, Silicon Dioxide, Pharmaceutical Vehicles, Porosity, Nanoparticles, Magnetic Fields

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