Development of Mesoporous Silica Nanomaterials As a Vehicle for Anticancer Drug Delivery
Open accessAbstract
The development of delivery vehicles that would carry therapeutic agents selectively to cancer cells has become an important focus in biomedical research. Nanoparticles have received much attention because the advances made in this field have resulted in multiple biocompatible materials. In particular, mesoporous silica nanoparticles (MSNs) offer a solid framework with porous structure and high surface area that allows for the attachment of different functional groups. In this article we discuss the different surface modifications made to MSNs that have allowed for the construction of targeted nanoparticles to enhance accumulation and uptake in target sites, the incorporation of nanomachines for controlled cargo release and the combination with superparamagnetic metals for MRI cell labeling. We also discuss biocompatibility, biodistribution and drug-delivery efficacy of MSNs. Finally, we mention the construction of multifunctional nanoparticles that combine all of the previously examined nanoparticle modifications.
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Mesoporous silica nanoparticles can have their surface altered for active targeting by adding peptides, folate, mannose, and transferrin.
“Mesoporous silica nanoparticles can have their surface altered for active targeting by adding peptides, folate, mannose, and transferrin.75–77”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [75]
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- Authors
- Yanes, R. E., & Tamanoi, F.
- Affiliations
- California NanoSystems Institute (US)
- Venue
- Therapeutic Delivery
- Publisher
- Informa UK Limited
- Published
- 2012-03
- Volume
- 3
- Issue
- 3
- Pages
- 389-404
- ISSN
- 2041-5990 (ISSN-L)
- 2041-6008
- PMC
- PMC3324307
- OpenAlex
- W2168557738
- Cited by
- 68
- References
- 89
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 2 · 2015: 9 · 2014: 5 · 2013: 5 · 2012: 2
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Therapeutic Delivery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA133697, CA 133697)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Mesoporous Materials and Catalysis
- Physical Sciences › Materials Science › Biomaterials › Clay minerals and soil interactions
- Keywords
- mesoporous silica nanoparticles, anticancer drug delivery, targeted drug delivery, surface modification, controlled release, superparamagnetic iron oxide nanoparticles, tissue distribution, biocompatibility, multifunctional nanoparticles, nanoparticle drug carriers
- MeSH terms
- Antineoplastic Agents, Exocytosis, Hydrogen-Ion Concentration, Silicon Dioxide, Pharmaceutical Vehicles, Porosity, Nanoparticles, Magnetic Fields
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