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Targeted Drug Delivery in Cancer Cells with Red-Light Photoactivated Mesoporous Silica Nanoparticles

Mackowiak, Stephan A., Schmidt, Alexandra, Weiss, Veronika, Argyo, Christian, von Schirnding, Constantin, Bein, Thomas, Bräuchle, Christoph·2013·Nano Letters
DOI 10.1021/nl400681f
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Abstract

Mesoporous nanoparticles for drug delivery would benefit significantly from further improvements in targeting efficiency and endosomal release. We present a system based on colloidal mesoporous silica nanoparticles with targeting-ligands and a red-light photosensitizer. This nanoparticle system provides spatial and temporal control of the release of drugs into the cytosol of cancer cells. Furthermore, the system presents a general platform since it can be loaded with different cargos and adapted for targeting of multiple cell types.

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Metadata

Authors
Mackowiak, S. A., Schmidt, A., Weiss, V., Argyo, C., von Schirnding, C., Bein, T., & Bräuchle, C.
Affiliations
Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstrasse 5-13(E), 81377 Munich, Germany
Venue
Nano Letters
Publisher
American Chemical Society (ACS)
Published
2013-05-16
Volume
13
Issue
6
Pages
2576-2583
ISSN
  • 1530-6984
  • 1530-6992
DOI
10.1021/nl400681f
Cited by
170
References
3
Language
en

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