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Hydrophobic Gold Nanoparticle Self-Assembly with Phosphatidylcholine Lipid: Membrane-Loaded and Janus Vesicles
Abstract
Hybrids of hydrophobic sub-2-nm-diameter dodecanethiol-coated Au nanoparticles and phosphatidylcholine (PC) lipid vesicles made by extrusion were examined by cryogenic transmission electron microscopy (cryoTEM). The nanoparticles loaded the vesicles as a dense monolayer in the hydrophobic core of the lipid bilayer, without disrupting their structure. Nanoparticle-vesicle hybrids could also be made by a dialysis process, mixing preformed vesicles with detergent-stabilized nanoparticles, but this approach led to vesicles only partially loaded with nanoparticles that segregated into hemispherical domains, forming a Janus vesicle-nanoparticle hybrid structure.
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Cites
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Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Cited by
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Amstad, E., Kohlbrecher, J., Müller, E., Schweizer, T., Textor, M., & Reimhult, E. (2011) · Nano Letters · doi:10.1021/nl2001499 · Cited by 397
Mousseau, F., Oikonomou, E. K., Baldim, V., Mornet, S., & Berret, J.-F. (2018) · Colloids and Interfaces · doi:10.3390/colloids2040050 · Cited by 10
Metadata
- Authors
- Rasch, M. R., Rossinyol, E., Hueso, J. L., Goodfellow, B. W., Arbiol, J., & Korgel, B. A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-08-23
- Volume
- 10
- Issue
- 9
- Pages
- 3733-3739
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1989130768
- Cited by
- 222
- References
- 1
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rasch, M. R., Rossinyol, E., Hueso, J. L., Goodfellow, B. W., Arbiol, J., & Korgel, B. A. (2010). Hydrophobic Gold Nanoparticle Self-Assembly with Phosphatidylcholine Lipid: Membrane-Loaded and Janus Vesicles. Nano Letters. https://doi.org/10.1021/nl102387n
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