Triggered release from liposomes through magnetic actuation of iron oxide nanoparticle containing membranes
Open accessAbstract
The ideal nanoscale drug delivery vehicle allows control over the released dose in space and time. We demonstrate that this can be achieved by stealth liposomes comprising self-assembled superparamagnetic iron oxide nanoparticles (NPs) individually stabilized with palmityl-nitroDOPA incorporated in the lipid membrane. Alternating magnetic fields were used to control timing and dose of repeatedly released cargo from such vesicles by locally heating the membrane, which changed its permeability without major effects on the environment.
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Iron oxide nanoparticles can be entrapped inside vesicles like liposomes or polymeric micelles.
“Iron oxide nanoparticles can be entrapped inside of vesicles like liposomes [94–97] or polymeric micelles [98–101].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [96]
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- Authors
- Amstad, E., Kohlbrecher, J., Müller, E., Schweizer, T., Textor, M., & Reimhult, E.
- Affiliations
- ETH Zurich (CH)
- Paul Scherrer Institute (CH)
- Corresponding author
- Reimhult, Erik
- ORCID
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-02-25
- Volume
- 11
- Issue
- 4
- Pages
- 1664-1670
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1988329232
- Cited by
- 397
- References
- 35
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 11 · 2023: 13 · 2022: 24 · 2021: 27 · 2020: 28 · 2019: 26 · 2018: 33 · 2017: 32 · 2016: 40 · 2015: 38 · 2014: 40 · 2013: 23 · 2012: 33
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- DORA PSI (Paul Scherrer Institute) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- triggered drug release, PEGylated liposomes, superparamagnetic iron oxide nanoparticles, magnetic actuation, alternating magnetic field heating, lipid membrane permeability, controlled drug delivery
- MeSH terms
- Pharmaceutical Preparations, Electromagnetic Fields, Ferric Compounds, Liposomes, Materials Testing, Membranes, Artificial, Permeability, Nanocapsules
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