Cited by 397Nanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesLipid Membrane Structure and Behavior

Triggered release from liposomes through magnetic actuation of iron oxide nanoparticle containing membranes

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Amstad, Esther, Kohlbrecher, Joachim, Müller, Elisabeth, Schweizer, Thomas, Textor, Marcus, Reimhult, Erik·2011·Nano Letters

Abstract

The ideal nanoscale drug delivery vehicle allows control over the released dose in space and time. We demonstrate that this can be achieved by stealth liposomes comprising self-assembled superparamagnetic iron oxide nanoparticles (NPs) individually stabilized with palmityl-nitroDOPA incorporated in the lipid membrane. Alternating magnetic fields were used to control timing and dose of repeatedly released cargo from such vesicles by locally heating the membrane, which changed its permeability without major effects on the environment.

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Crossref · 10.1021/nl2001499

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35 of 35 references verified0 citation errors · 0 not checkable

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Authors
Amstad, E., Kohlbrecher, J., Müller, E., Schweizer, T., Textor, M., & Reimhult, E.
Affiliations
  • ETH Zurich (CH)
  • Paul Scherrer Institute (CH)
Corresponding author
Reimhult, Erik
Venue
Nano Letters
Published
2011-02-25
Volume
11
Issue
4
Pages
1664-1670
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
OpenAlex
W1988329232
Cited by
397
References
35
Citations by year
2026: 8 · 2025: 17 · 2024: 11 · 2023: 13 · 2022: 24 · 2021: 27 · 2020: 28 · 2019: 26 · 2018: 33 · 2017: 32 · 2016: 40 · 2015: 38 · 2014: 40 · 2013: 23 · 2012: 33
FWCI
13.09
Type
journal article
Language
en
Open access
Locations
  • Nano Letters (publishedVersion)
  • PubMed (publishedVersion)
  • DORA PSI (Paul Scherrer Institute) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
triggered drug release, PEGylated liposomes, superparamagnetic iron oxide nanoparticles, magnetic actuation, alternating magnetic field heating, lipid membrane permeability, controlled drug delivery
MeSH terms
Pharmaceutical Preparations, Electromagnetic Fields, Ferric Compounds, Liposomes, Materials Testing, Membranes, Artificial, Permeability, Nanocapsules

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