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Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy
Abstract
We have observed that Au nanorods (NRs) have distinct effects on cell viability via killing cancer cells while posing negligible impact on normal cells and mesenchymal stem cells. Obvious differences in cellular uptake, intracellular trafficking, and susceptibility of lysosome to Au NRs by different types of cells resulted in selective accumulation of Au NRs in the mitochondria of cancer cells. Their long-term retention decreased mitochondrial membrane potential and increased reactive oxygen species level that enhances the likelihood of cell death. These findings thus provide guidance for the design of organelle-targeted nanomaterials in tumor therapy.
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Cited by
Cellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859
Recent biomedical applications of gold nanoparticles: A review
Elahi, N., Kamali, M., & Baghersad, M. H. (2018) · Talanta · doi:10.1016/j.talanta.2018.02.088 · Cited by 1,174
Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate
Zhu, M., Nie, G., Meng, H., Xia, T., Nel, A., & Zhao, Y. (2013) · Accounts of Chemical Research · doi:10.1021/ar300031y · Cited by 803
Self-citationJiang, Y., Huo, S., Mizuhara, T., Das, R., Lee, Y.-W., Hou, S., Moyano, D. F., Duncan, B., Liang, X.-J., & Rotello, V. M. (2015) · ACS Nano · doi:10.1021/acsnano.5b03521 · Cited by 401
The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective
Awashra, M., & Młynarz, P. (2023) · Nanoscale Advances · doi:10.1039/d2na00534d · Cited by 319
Metadata
- Authors
- Wang, L., Liu, Y., Li, W., Jiang, X., Ji, Y., Wu, X., Xu, L., Qiu, Y., Zhao, K., Wei, T., Li, Y., Zhao, Y., & Chen, C.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-02-09
- Volume
- 11
- Issue
- 2
- Pages
- 772-780
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1972695628
- Cited by
- 514
- References
- 0
- FWCI
- 18.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy. https://app.cochat.ai/papers/10.1021/nl103992v
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- Wang, L., Liu, Y., Li, W., Jiang, X., Ji, Y., Wu, X., Xu, L., Qiu, Y., Zhao, K., Wei, T., Li, Y., Zhao, Y., & Chen, C. (2011). Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy. Nano Letters. https://doi.org/10.1021/nl103992v
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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