The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The Interplay of Size and Surface Functionality on the Cellular Uptake of Sub-10 nm Gold Nanoparticles
Open accessAbstract
Correlation of the surface physicochemical properties of nanoparticles with their interactions with biosystems provides key foundational data for nanomedicine. We report here the systematic synthesis of 2, 4, and 6 nm core gold nanoparticles (AuNP) featuring neutral (zwitterionic), anionic, and cationic headgroups. The cellular internalization of these AuNPs was quantified, providing a parametric evaluation of charge and size effects. Contrasting behavior was observed with these systems: with zwitterionic and anionic particles, uptake decreased with increasing AuNP size, whereas with cationic particles, uptake increased with increasing particle size. Through mechanistic studies of the uptake process, we can attribute these opposing trends to a surface-dictated shift in uptake pathways. Zwitterionic NPs are primarily internalized through passive diffusion, while the internalization of cationic and anionic NPs is dominated by multiple endocytic pathways. Our study demonstrates that size and surface charge interact in an interrelated fashion to modulate nanoparticle uptake into cells, providing an engineering tool for designing nanomaterials for specific biological applications.
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Cites
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The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990
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Emerging understanding of the protein corona at the nano-bio interfaces
Mahmoudi, M., Bertrand, N., Zope, H., & Farokhzad, O. C. (2016) · Nano Today · doi:10.1016/j.nantod.2016.10.005 · Cited by 250
Nanoparticle Transport Across the Placental Barrier: Pushing the Field Forward!
Muoth, C., Aengenheister, L., Kucki, M., Wick, P., & Buerki-Thurnherr, T. (2016) · Nanomedicine · doi:10.2217/nnm-2015-0012 · Cited by 146
Płuciennik, K., Sicińska, P., Misztal, W., & Bukowska, B. (2024) · Cells · doi:10.3390/cells13090768 · Cited by 132
Metadata
- Authors
- Jiang, Y., Huo, S., Mizuhara, T., Das, R., Lee, Y.-W., Hou, S., Moyano, D. F., Duncan, B., Liang, X.-J., & Rotello, V. M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-10-07
- Volume
- 9
- Issue
- 10
- Pages
- 9986-9993
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2300904217
- Cited by
- 401
- References
- 42
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Jiang, Y., Huo, S., Mizuhara, T., Das, R., Lee, Y.-W., Hou, S., Moyano, D. F., Duncan, B., Liang, X.-J., & Rotello, V. M. (2015). The Interplay of Size and Surface Functionality on the Cellular Uptake of Sub-10 nm Gold Nanoparticles. ACS Nano. https://doi.org/10.1021/acsnano.5b03521
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