The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Magnetically Triggered Nanocomposite Membranes: A Versatile Platform for Triggered Drug Release
Open accessAbstract
Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field. We show that the dose of drug delivered across the membrane can be tuned by engineering the phase transition temperature of the nanogel, the loading density of nanogels in the membrane, and the membrane thickness, allowing for on-state delivery of model drugs over at least 2 orders of magnitude (0.1-10 μg/h). The zero-order kinetics of drug release across the membranes permit drug doses from a specific device to be tuned according to the duration of the magnetic field. Drugs over a broad range of molecular weights (500-40000 Da) can be delivered by the same membrane device. Membrane-to-membrane and cycle-to-cycle reproducibility is demonstrated, suggesting the general utility of these membranes for drug delivery.
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Citations
Cites
Biocompatibility and drug delivery systems
Kohane, D. S., & Langer, R. (2010) · Chem. Sci. · doi:10.1039/c0sc00203h · Cited by 307
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Cited by
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Sahandi Zangabad, P., Rahighi, R., Moosavi Basri, S. M., Mirshekari, H., Amiri, M., Shafaei Pishabad, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,519
Treating metastatic cancer with nanotechnology
Schroeder, A., Heller, D. A., Winslow, M. M., Dahlman, J. E., Pratt, G. W., Langer, R., Jacks, T., & Anderson, D. G. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3180 · Cited by 1,159
Self-citationIron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery
Estelrich, J., Escribano, E., Queralt, J., & Busquets, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16048070 · Cited by 532
Photoresponsive nanoparticles for drug delivery
Rwei, A. Y., Wang, W., & Kohane, D. S. (2015) · Nano Today · doi:10.1016/j.nantod.2015.06.004 · Cited by 318
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Metadata
- Authors
- Hoare, T., Timko, B. P., Santamaria, J., Goya, G. F., Irusta, S., Lau, S., Stefanescu, C. F., Lin, D., Langer, R., & Kohane, D. S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-02-23
- Volume
- 11
- Issue
- 3
- Pages
- 1395-1400
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2225272122
- Cited by
- 247
- References
- 1
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- green
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