The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Gold Nanoparticles: A Revival in Precious Metal Administration to Patients
Open accessAbstract
Gold has been used as a therapeutic agent to treat a wide variety of rheumatic diseases including psoriatic arthritis, juvenile arthritis, and discoid lupus erythematosus. Although the use of gold has been largely superseded by newer drugs, gold nanoparticles are being used effectively in laboratory based clinical diagnostic methods while concurrently showing great promise in vivo either as a diagnostic imaging agent or a therapeutic agent. For these reasons, gold nanoparticles are therefore well placed to enter mainstream clinical practice in the near future. Hence, the present review summarizes the chemistry, pharmacokinetics, biodistribution, metabolism, and toxicity of bulk gold in humans based on decades of clinical observation and experiments in which gold was used to treat patients with rheumatoid arthritis. The beneficial attributes of gold nanoparticles, such as their ease of synthesis, functionalization, and shape control are also highlighted demonstrating why gold nanoparticles are an attractive target for further development and optimization. The importance of controlling the size and shape of gold nanoparticles to minimize any potential toxic side effects is also discussed.
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Cites
Chemistry and Properties of Nanocrystals of Different Shapes
Burda, C., Chen, X., Narayanan, R., & El-Sayed, M. A. (2005) · Chemical Reviews · doi:10.1021/cr030063a · Cited by 7,230
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533
Immunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds
Kwon, G. S. (2003) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v20.i5.20 · Cited by 502
The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice
Thakor, A. S., Luong, R., Paulmurugan, R., Lin, F. I., Kempen, P., Zavaleta, C., Chu, P., Massoud, T. F., Sinclair, R., & Gambhir, S. S. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001963 · Cited by 159
Self-citation
Cited by
Recent biomedical applications of gold nanoparticles: A review
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Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances
Kaul, S., Gulati, N., Verma, D., Mukherjee, S., & Nagaich, U. (2018) · Journal of Pharmaceutics · doi:10.1155/2018/3420204 · Cited by 435
Magneto‐Plasmonic Au‐Fe Alloy Nanoparticles Designed for Multimodal SERS‐MRI‐CT Imaging
Amendola, V., Scaramuzza, S., Litti, L., Meneghetti, M., Zuccolotto, G., Rosato, A., Nicolato, E., Marzola, P., Fracasso, G., Anselmi, C., et al. (2014) · Small · doi:10.1002/smll.201303372 · Cited by 189
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Metadata
- Authors
- Thakor, A. S., Jokerst, J., Zavaleta, C., Massoud, T. F., & Gambhir, S. S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-09-07
- Volume
- 11
- Issue
- 10
- Pages
- 4029-4036
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2091854840
- Cited by
- 468
- References
- 5
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
