The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes
Abstract
Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges.
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Cites
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Cited by
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Physical Principles of Nanoparticle Cellular Endocytosis
Zhang, S., Gao, H., & Bao, G. (2015) · ACS Nano · doi:10.1021/acsnano.5b03184 · Cited by 1,103
The importance of nanoparticle shape in cancer drug delivery
Truong, N. P., Whittaker, M. R., Mak, C. W., & Davis, T. P. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.950564 · Cited by 594
Jin, R., Lin, B., Li, D., & Ai, H. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.08.002 · Cited by 305
Smith, D. J., Leal, L. G., Mitragotri, S., & Shell, M. S. (2018) · Journal of Physics D: Applied Physics · doi:10.1088/1361-6463/aacac9 · Cited by 23
Metadata
- Authors
- Vácha, R., Martinez-Veracoechea, F. J., & Frenkel, D.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-11-07
- Volume
- 11
- Issue
- 12
- Pages
- 5391-5395
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1989945146
- Cited by
- 494
- References
- 18
- FWCI
- 12.72
- Type
- journal article
- Language
- en
- Open access
- closed
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