The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Optical Trapping of a Single Protein
Abstract
We experimentally demonstrate the optical trapping of a single bovine serum albumin (BSA) molecule that has a hydrodynamic radius of 3.4 nm, using a double-nanohole in an Au film. The strong optical force in the trap not only stably traps the protein molecule but also unfolds it. The unfolding of the BSA is confirmed by experiments with changing optical power and with changing solution pH. The detection of the trapping event has a signal-to-noise ratio of 33, which shows that the setup is extremely sensitive to detect the presence of a protein, even at the single molecule level.
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Citations
Cites
Observation of a single-beam gradient force optical trap for dielectric particles
Ashkin, A., Dziedzic, J. M., Bjorkholm, J. E., & Chu, S. (1986) · Optics Letters · doi:10.1364/ol.11.000288 · Cited by 7,030
Biosensing with plasmonic nanosensors
Anker, J. N., Hall, W. P., Lyandres, O., Shah, N. C., Zhao, J., & Van Duyne, R. P. (2008) · Nature Materials · doi:10.1038/nmat2162 · Cited by 6,786
Carter, D. C., & Ho, J. X. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60640-3 · Cited by 3,187
Optical Trapping and Manipulation of Viruses and Bacteria
Ashkin, A., & Dziedzic, J. M. (1987) · Science · doi:10.1126/science.3547653 · Cited by 2,191
Single myosin molecule mechanics: piconewton forces and nanometre steps
Finer, J. T., Simmons, R. M., & Spudich, J. A. (1994) · Nature · doi:10.1038/368113a0 · Cited by 1,915
Whispering-gallery-mode biosensing: label-free detection down to single molecules
Vollmer, F., & Arnold, S. (2008) · Nature Methods · doi:10.1038/nmeth.1221 · Cited by 1,660
Stretching DNA with optical tweezers
Wang, M. D., Yin, H., Landick, R., Gelles, J., & Block, S. M. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78780-0 · Cited by 1,481
Direct observation of base-pair stepping by RNA polymerase
Abbondanzieri, E. A., Greenleaf, W. J., Shaevitz, J. W., Landick, R., & Block, S. M. (2005) · Nature · doi:10.1038/nature04268 · Cited by 855
Immunosensors—principles and applications to clinical chemistry
Luppa, P. B., Sokoll, L. J., & Chan, D. W. (2001) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00629-5 · Cited by 741
Ostuni, E., Chapman, R. G., Liang, M. N., Meluleni, G., Pier, G., Ingber, D. E., & Whitesides, G. M. (2001) · Langmuir · doi:10.1021/la010552a · Cited by 563
Dholakia, K., Reece, P., & Gu, M. (2008) · Chem. Soc. Rev. · doi:10.1039/b512471a · Cited by 345
High sensitivity nanoparticle detection using optical microcavities
Lu, T., Lee, H., Chen, T., Herchak, S., Kim, J.-H., Fraser, S. E., Flagan, R. C., & Vahala, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017962108 · Cited by 308
Nanomanipulation Using Silicon Photonic Crystal Resonators
Mandal, S., Serey, X., & Erickson, D. (2010) · Nano Letters · doi:10.1021/nl9029225 · Cited by 301
Optical Trapping of 12 nm Dielectric Spheres Using Double-Nanoholes in a Gold Film
Pang, Y., & Gordon, R. (2011) · Nano Letters · doi:10.1021/nl201807z · Cited by 275
Self-citationGeometry-induced electrostatic trapping of nanometric objects in a fluid
Krishnan, M., Mojarad, N., Kukura, P., & Sandoghdar, V. (2010) · Nature · doi:10.1038/nature09404 · Cited by 240
Optical Manipulation with Planar Silicon Microring Resonators
Lin, S., Schonbrun, E., & Crozier, K. (2010) · Nano Letters · doi:10.1021/nl100501d · Cited by 236
Liu, Y., Sonek, G. J., Berns, M. W., & Tromberg, B. J. (1996) · Biophysical Journal · doi:10.1016/s0006-3495(96)79417-1 · Cited by 198
Optimized optical trapping of gold nanoparticles
Hajizadeh, F., & S.Reihani, S. N. (2010) · Optics Express · doi:10.1364/oe.18.000551 · Cited by 190
Quantitative Optical Trapping of Single Gold Nanorods
Selhuber-Unkel, C., Zins, I., Schubert, O., Sönnichsen, C., & Oddershede, L. B. (2008) · Nano Letters · doi:10.1021/nl802053h · Cited by 183
Moriyama, Y., Watanabe, E., Kobayashi, K., Harano, H., Inui, E., & Takeda, K. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp8067624 · Cited by 155
Lee, C. T., Smith, K. A., & Hatton, T. A. (2004) · Biochemistry · doi:10.1021/bi048556c · Cited by 126
All-Optical Patterning of Au Nanoparticles on Surfaces Using Optical Traps
Guffey, M. J., & Scherer, N. F. (2010) · Nano Letters · doi:10.1021/nl904167t · Cited by 125
Forces and Transport Velocities for a Particle in a Slot Waveguide
Yang, A. H. J., Lerdsuchatawanich, T., & Erickson, D. (2009) · Nano Letters · doi:10.1021/nl803832q · Cited by 123
Plasmonic Nanobilliards: Controlling Nanoparticle Movement Using Forces Induced by Swift Electrons
Batson, P. E., Reyes–Coronado, A., Barrera, R. G., Rivacoba, A., Echenique, P. M., & Aizpurua, J. (2011) · Nano Letters · doi:10.1021/nl201795u · Cited by 97
Optical Trapping with Integrated Near-Field Apertures
Kwak, E.-S., Onuta, T., Amarie, D., Potyrailo, R. A., Stein, B. D., Jacobson, S. C., Schaich, W. L., & Dragnea, B. G. (2004) · The Journal of Physical Chemistry B · doi:10.1021/jp048028a · Cited by 91
Characterization of Semiconductor Nanowires Using Optical Tweezers
Reece, P. J., Toe, W. J., Wang, F., Paiman, S. B., Gao, Q., Tan, H. H., & Jagadish, C. (2011) · Nano Letters · doi:10.1021/nl200720m · Cited by 87
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Yoo, D., Gurunatha, K. L., Choi, H.-K., Mohr, D. A., Ertsgaard, C. T., Gordon, R., & Oh, S.-H. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00732 · Cited by 173
Self-citationOptical Monitoring of In Situ Iron Loading into Single, Native Ferritin Proteins
Yousefi, A., Ying, C., Parmenter, C. D. J., Assadipapari, M., Sanderson, G., Zheng, Z., Xu, L., Zargarbashi, S., Hickman, G. J., Cousins, R. B., et al. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c00042 · Cited by 37
Metadata
- Authors
- Pang, Y., & Gordon, R.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-12-16
- Volume
- 12
- Issue
- 1
- Pages
- 402-406
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2073614756
- Cited by
- 503
- References
- 26
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- closed
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