The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
High sensitivity nanoparticle detection using optical microcavities
Open accessAbstract
We demonstrate a highly sensitive nanoparticle and virus detection method by using a thermal-stabilized reference interferometer in conjunction with an ultrahigh-Q microcavity. Sensitivity is sufficient to resolve shifts caused by binding of individual nanobeads in solution down to a record radius of 12.5 nm, a size approaching that of single protein molecules. A histogram of wavelength shift versus nanoparticle radius shows that particle size can be inferred from shift maxima. Additionally, the signal-to-noise ratio for detection of Influenza A virus is enhanced to 38∶1 from the previously reported 3∶1. The method does not use feedback stabilization of the probe laser. It is also observed that the conjunction of particle-induced backscatter and optical-path-induced shifts can be used to enhance detection signal-to-noise.
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Citations
Cites
Vahala, K. J. (2003) · Nature · doi:10.1038/nature01939 · Cited by 4,878
Self-citationUltra-high-Q toroid microcavity on a chip
Armani, D. K., Kippenberg, T. J., Spillane, S. M., & Vahala, K. J. (2003) · Nature · doi:10.1038/nature01371 · Cited by 2,214
Self-citation
Cited by
Zijlstra, P., Paulo, P. M. R., & Orrit, M. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.51 · Cited by 788
Optical Trapping of a Single Protein
Pang, Y., & Gordon, R. (2012) · Nano Letters · doi:10.1021/nl203719v · Cited by 503
Metadata
- Authors
- Lu, T., Lee, H., Chen, T., Herchak, S., Kim, J.-H., Fraser, S. E., Flagan, R. C., & Vahala, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-03-28
- Volume
- 108
- Issue
- 15
- Pages
- 5976-5979
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042024782
- Cited by
- 308
- References
- 2
- FWCI
- 23.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lu, T., Lee, H., Chen, T., Herchak, S., Kim, J.-H., Fraser, S. E., Flagan, R. C., & Vahala, K. (2011). High sensitivity nanoparticle detection using optical microcavities. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1017962108
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