The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Single Unlabeled Protein Detection on Individual Plasmonic Nanoparticles
Abstract
The ultimate detection limit in analytic chemistry and biology is the single molecule. Commonly, fluorescent dye labels or enzymatic amplification are employed. This requires additional labeling of the analyte, which modifies the species under investigation and therefore influences biological processes. Here, we utilize single gold nanoparticles to detect single unlabeled proteins with extremely high temporal resolution. This allows for monitoring the dynamic evolution of a single protein binding event on a millisecond time scale. The technique even resolves equilibrium coverage fluctuations, opening a window into Brownian dynamics of unlabeled macromolecules. Therefore, our method enables the study of protein folding dynamics, protein adsorption processes, and kinetics as well as nonequilibrium soft matter dynamics on the single molecule level.
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Citations
Cites
Vahala, K. J. (2003) · Nature · doi:10.1038/nature01939 · Cited by 4,878
Dynamic personalities of proteins
Henzler-Wildman, K., & Kern, D. (2007) · Nature · doi:10.1038/nature06522 · Cited by 2,545
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Metadata
- Authors
- Ament, I., Prasad, J., Henkel, A., Schmachtel, S., & Sönnichsen, C.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-01-31
- Volume
- 12
- Issue
- 2
- Pages
- 1092-1095
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2055447532
- Cited by
- 335
- References
- 2
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
