The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Water-Dispersible Ferrimagnetic Iron Oxide Nanocubes with Extremely High r2 Relaxivity for Highly Sensitive in Vivo MRI of Tumors
Abstract
The theoretically predicted maximum r(2) relaxivity of iron oxide nanoparticles was achieved by optimizing the overall size of ferrimagnetic iron oxide nanocubes. Uniform-sized iron oxide nanocubes with an edge length of 22 nm, encapsulated with PEG-phospholipids (WFION), exhibited high colloidal stability in aqueous media. In addition, WFIONs are biocompatible and did not affect cell viability at concentrations up to 0.75 mg Fe/ml. Owing to the enhanced colloidal stability and the high r(2) relaxivity (761 mM(-1) s(-1)), it was possible to successfully perform in vivo MR imaging of tumors by intravenous injection of 22-nm-sized WFIONs, using a clinical 3-T MR scanner.
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Self-citationMultifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications
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Inorganic Nanoparticles for MRI Contrast Agents
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Cited by
Tuning the Magnetic Properties of Nanoparticles
Kolhatkar, A., Jamison, A., Litvinov, D., Willson, R., & Lee, T. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140815977 · Cited by 820
Organic Phase Syntheses of Magnetic Nanoparticles and Their Applications
Wu, L., Mendoza-Garcia, A., Li, Q., & Sun, S. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00687 · Cited by 601
Chemical Synthesis and Assembly of Uniformly Sized Iron Oxide Nanoparticles for Medical Applications
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Self-citationKandasamy, G., & Maity, D. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.10.058 · Cited by 422
Testa-Anta, M., Ramos-Docampo, M. A., Comesaña-Hermo, M., Rivas-Murias, B., & Salgueiriño, V. (2019) · Nanoscale Advances · doi:10.1039/c9na00064j · Cited by 298
Metadata
- Authors
- Lee, N., Choi, Y., Lee, Y., Park, M., Moon, W. K., Choi, S. H., & Hyeon, T.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-14
- Volume
- 12
- Issue
- 6
- Pages
- 3127-3131
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2326155974
- Cited by
- 293
- References
- 47
- FWCI
- 16.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, N., Choi, Y., Lee, Y., Park, M., Moon, W. K., Choi, S. H., & Hyeon, T. (2012). Water-Dispersible Ferrimagnetic Iron Oxide Nanocubes with Extremely High r2 Relaxivity for Highly Sensitive in Vivo MRI of Tumors. Nano Letters. https://doi.org/10.1021/nl3010308
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
