The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Self-Assembled DNA Nanopores That Span Lipid Bilayers
Abstract
DNA nanotechnology excels at rationally designing bottom-up structures that can functionally replicate naturally occurring proteins. Here we describe the design and generation of a stable DNA-based nanopore that structurally mimics the amphiphilic nature of protein pores and inserts into bilayers to support a steady transmembrane flow of ions. The pore carries an outer hydrophobic belt comprised of small chemical alkyl groups which mask the negatively charged oligonucleotide backbone. This modification overcomes the otherwise inherent energetic mismatch to the hydrophobic environment of the membrane. By merging the fields of nanopores and DNA nanotechnology, we expect that the small membrane-spanning DNA pore will help open up the design of entirely new molecular devices for a broad range of applications including sensing, electric circuits, catalysis, and research into nanofluidics and controlled transmembrane transport.
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Cites
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The potential and challenges of nanopore sequencing
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Structure of Staphylococcal α-Hemolysin, a Heptameric Transmembrane Pore
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Continuous base identification for single-molecule nanopore DNA sequencing
Clarke, J., Wu, H.-C., Jayasinghe, L., Patel, A., Reid, S., & Bayley, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.12 · Cited by 1,810
Nanopore sensors for nucleic acid analysis
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Rapid prototyping of 3D DNA-origami shapes with caDNAno
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Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication
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Cited by
DNA Nanotechnology-Enabled Drug Delivery Systems
Hu, Q., Li, H., Wang, L., Gu, H., & Fan, C. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00663 · Cited by 1,118
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
Meng, H.-M., Liu, H., Kuai, H., Peng, R., Mo, L., & Zhang, X.-B. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00645g · Cited by 608
Howorka, S. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.99 · Cited by 293
Self-citation
Metadata
- Authors
- Burns, J. R., Stulz, E., & Howorka, S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-04-30
- Volume
- 13
- Issue
- 6
- Pages
- 2351-2356
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1967952840
- Cited by
- 298
- References
- 59
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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