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DNA Nanotechnology-Enabled Drug Delivery Systems
Abstract
Over the past decade, we have seen rapid advances in applying nanotechnology in biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA nanotechnology offers simple yet powerful design techniques for self-assembly of nanostructures with unique advantages and high potential in enhancing drug targeting and reducing drug toxicity. Various sequence programming and optimization approaches have been developed to design DNA nanostructures with precisely engineered, controllable size, shape, surface chemistry, and function. Potent anticancer drug molecules, including Doxorubicin and CpG oligonucleotides, have been successfully loaded on DNA nanostructures to increase their cell uptake efficiency. These advances have implicated the bright future of DNA nanotechnology-enabled nanomedicine. In this review, we begin with the origin of DNA nanotechnology, followed by summarizing state-of-the-art strategies for the construction of DNA nanostructures and drug payloads delivered by DNA nanovehicles. Further, we discuss the cellular fates of DNA nanostructures as well as challenges and opportunities for DNA nanostructure-based drug delivery.
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Cites
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Kelly, K. L., Coronado, E., Zhao, L. L., & Schatz, G. C. (2003) · The Journal of Physical Chemistry B · doi:10.1021/jp026731y · Cited by 10,594
Folding DNA to create nanoscale shapes and patterns
Rothemund, P. W. K. (2006) · Nature · doi:10.1038/nature04586 · Cited by 7,354
The new frontier of genome engineering with CRISPR-Cas9
Doudna, J. A., & Charpentier, E. (2014) · Science · doi:10.1126/science.1258096 · Cited by 7,062
Magnetic Nanoparticles: Synthesis, Protection, Functionalization, and Application
Lu, A., Salabas, E. L., & Schüth, F. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200602866 · Cited by 6,777
A DNA-based method for rationally assembling nanoparticles into macroscopic materials
Mirkin, C. A., Letsinger, R. L., Mucic, R. C., & Storhoff, J. J. (1996) · Nature · doi:10.1038/382607a0 · Cited by 6,683
Global quantification of mammalian gene expression control
Schwanhäusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W., & Selbach, M. (2011) · Nature · doi:10.1038/nature10098 · Cited by 6,566
A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer
Paik, S., Shak, S., Tang, G., Kim, C., Baker, J., Cronin, M., Baehner, F. L., Walker, M. G., Watson, D., Park, T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041588 · Cited by 6,277
Development and Applications of CRISPR-Cas9 for Genome Engineering
Hsu, P. D., Lander, E. S., & Zhang, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.010 · Cited by 5,762
Genome-scale CRISPR-Cas9 knockout screening in human cells
Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., Heckl, D., Ebert, B. L., Root, D. E., Doench, J. G., et al. (2014) · Science · doi:10.1126/science.1247005 · Cited by 5,234
Research works printed but not linked: 36
- Langer R., 1998, Nature, 392, 5
- 10.1021/nl204098n · doi:10.1021/nl204098n
- 10.1038/nnano.2015.246 · doi:10.1038/nnano.2015.246
- 10.1002/smll.201101365 · doi:10.1002/smll.201101365
- 10.1073/pnas.1513058112 · doi:10.1073/pnas.1513058112
- 10.1002/anie.201508845 · doi:10.1002/anie.201508845
- 10.1038/nnano.2015.259 · doi:10.1038/nnano.2015.259
- 10.1002/anie.201506312 · doi:10.1002/anie.201506312
- 10.1021/bi00237a005 · doi:10.1021/bi00237a005
- 10.1002/ange.200904513 · doi:10.1002/ange.200904513
- 10.1002/1521-3773(20010803)40:15<2909::AID-ANIE2909>3.0.CO;2-O · doi:10.1002/1521-3773(20010803)40:15<2909::aid-anie2909>3.0.co;2-o
- 10.1021/bc100160k · doi:10.1021/bc100160k
- 10.1016/j.biomaterials.2015.04.037 · doi:10.1016/j.biomaterials.2015.04.037
- Jain R. K., 1990, Cancer Res., 50, 814s
- 10.1124/mol.57.4.679 · doi:10.1124/mol.57.4.679 · Paper page
- Raz A., 1981, Cancer Res., 41, 487
- Lee A. G., 1996, Endocytosis and Exocytosis
- Strømhaug P., 1997, Eur. J. Cell Biol., 73, 28
- 10.1021/ja056656f · doi:10.1021/ja056656f
- 10.1021/acs.nanolett.7b00159 · doi:10.1021/acs.nanolett.7b00159
- 10.2147/IJN.S132929 · doi:10.2147/ijn.s132929
- Sachdeva M., 2010, Am. J. Transl. Res., 2, 170
- 10.1002/smll.200900848 · doi:10.1002/smll.200900848
- 10.1007/978-1-59745-561-9_21 · doi:10.1007/978-1-59745-561-9_21
- Mongelard F., 2010, Curr. Opin. Mol. Ther., 12, 107
- 10.1002/anie.201302759 · doi:10.1002/anie.201302759
- 10.1093/nar/gkw845 · doi:10.1093/nar/gkw845
- 10.1021/nn5015962 · DOI · Paper page
- 10.1002/cbic.201402100 · doi:10.1002/cbic.201402100
- 10.1002/ange.200906232 · doi:10.1002/ange.200906232
- 10.1021/bm201656k · doi:10.1021/bm201656k
- Yah C. S., 2012, Pak. J. Pham. Sci., 25, 477
- 10.1038/nnano.2016.150 · doi:10.1038/nnano.2016.150
- 10.1016/j.ymeth.2013.04.002 · doi:10.1016/j.ymeth.2013.04.002
- 10.1002/smll.201302993 · doi:10.1002/smll.201302993
- 10.1017/S1464793100005595 · doi:10.1017/s1464793100005595 · Paper page
Cited by
Emerging Applications of Nanotechnology in Healthcare and Medicine
Malik, S., Muhammad, K., & Waheed, Y. (2023) · Molecules · doi:10.3390/molecules28186624 · Cited by 610
DNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications
Dong, Y., Yao, C., Zhu, Y., Yang, L., Luo, D., & Yang, D. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00294 · Cited by 533
Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Nuclease resistance of DNA nanostructures
Chandrasekaran, A. R. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-021-00251-y · Cited by 382
Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
Mahmoodi Chalbatani, G., Dana, H., Gharagouzloo, E., Grijalvo, S., Eritja, R., Logsdon, C. D., Memari, F., Miri, S. R., Rezvani Rad, M., & Marmari, V. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s200253 · Cited by 221
Metadata
- Authors
- Hu, Q., Li, H., Wang, L., Gu, H., & Fan, C.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-02-21
- Volume
- 119
- Issue
- 10
- Pages
- 6459-6506
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2788055013
- Cited by
- 1,118
- References
- 399
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Funders
- Ministry of Science and Technology of the People's Republic of China (2016YFC1306403, 2016YFA0201200, 2016YFA0400900)
- China Postdoctoral Science Foundation (2017M611453)
- National Natural Science Foundation of China (21390414, 21673050, 21675167, 81500229)
- Chinese Academy of Sciences (QYZDJ-SSW-SLH031)
- Central Committee of the Communist Party of China (KHH1340004)
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