The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Subnanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles
Open accessAbstract
Local heating can be produced by iron oxide nanoparticles (IONPs) when exposed to an alternating magnetic field (AMF). To measure the temperature profile at the nanoparticle surface with a subnanometer resolution, here we present a molecular temperature probe based on the thermal decomposition of a thermo-sensitive molecule, namely, azobis[N-(2-carboxyethyl)-2-methylpropionamidine]. Fluoresceineamine (FA) was bound to the azo molecule at the IONP surface functionalized with poly(ethylene glycol) (PEG) spacers of different molecular weights. Significant local heating, with a temperature increase up to 45 °C, was found at distances below 0.5 nm from the surface of the nanoparticle, which decays exponentially with increasing distance. Furthermore, the temperature increase was found to scale linearly with the applied field at all distances. We implemented these findings in an AMF-triggered drug release system in which doxorubicin was covalently linked at different distances from the IONP surface bearing the same thermo-labile azo molecule. We demonstrated the AMF triggered distance-dependent release of the drug in a cytotoxicity assay on KB cancer cells.
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Cites
Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles
Laurent, S., Dutz, S., Häfeli, U. O., & Mahmoudi, M. (2011) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2011.04.003 · Cited by 1,326
Guardia, P., Di Corato, R., Lartigue, L., Wilhelm, C., Espinosa, A., Garcia-Hernandez, M., Gazeau, F., Manna, L., & Pellegrino, T. (2012) · ACS Nano · doi:10.1021/nn2048137 · Cited by 752
Self-citation
Cited by
Fundamentals and advances in magnetic hyperthermia
Périgo, E. A., Hemery, G., Sandre, O., Ortega, D., Garaio, E., Plazaola, F., & Teran, F. J. (2015) · Applied Physics Reviews · doi:10.1063/1.4935688 · Cited by 836
Dutz, S., & Hergt, R. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.822993 · Cited by 522
Mechanisms of drug release in nanotherapeutic delivery systems
Wong, P. T., & Choi, S. K. (2015) · Chemical Reviews · doi:10.1021/cr5004634 · Cited by 507
Improved water electrolysis using magnetic heating of FeC–Ni core–shell nanoparticles
Niether, C., Faure, S., Bordet, A., Deseure, J., Chatenet, M., Carrey, J., Chaudret, B., & Rouet, A. (2018) · Nature Energy · doi:10.1038/s41560-018-0132-1 · Cited by 499
Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications
Zhao, N., Yan, L., Zhao, X., Chen, X., Li, A., Zheng, D., Zhou, X., Dai, X., & Xu, F.-J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00401 · Cited by 429
Metadata
- Authors
- Riedinger, A., Guardia, P., Curcio, A., Garcia, M. A., Cingolani, R., Manna, L., & Pellegrino, T.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-05-09
- Volume
- 13
- Issue
- 6
- Pages
- 2399-2406
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2325692281
- Cited by
- 427
- References
- 2
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Riedinger, A., Guardia, P., Curcio, A., Garcia, M. A., Cingolani, R., Manna, L., & Pellegrino, T. (2013). Subnanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles. Nano Letters. https://doi.org/10.1021/nl400188q
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