Ultrasensitive silicon nanowire for real-world gas sensing: Noninvasive diagnosis of cancer from breath volatolome
Abstract
We report on an ultrasensitive, molecularly modified silicon nanowire field effect transistor that brings together the lock-and-key and cross-reactive sensing worlds for the diagnosis of (gastric) cancer from exhaled volatolome. The sensor is able to selectively detect volatile organic compounds (VOCs) that are linked with gastric cancer conditions in exhaled breath and to discriminate them from environmental VOCs that exist in exhaled breath samples but do not relate to the gastric cancer per se. Using breath samples collected from actual patients with gastric cancer and from volunteers who do not have cancer, blind analysis validated the ability of the reported sensor to discriminate between gastric cancer and control conditions with >85% accuracy, irrespective of important confounding factors such as tobacco consumption and gender. The reported sensing approach paves the way to use the power of silicon nanowires for simple, inexpensive, portable, and noninvasive diagnosis of cancer and other disease conditions.
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ANN model-assisted Si-nanowire FETs detected volatile organic compounds in breath prints from lung cancer, gastric cancer, and asthma and chronic obstructive pulmonary disease patients, and early diagnostic stages of cancer.
“Another example of using wearable AI-based biosensors is the detection of volatile organic compounds (VOCs) using ANN model-assisted Si-nanowire FETs in breath prints from lung cancer, gastric cancer, and asthma and chronic obstructive pulmonary disease patients, and early diagnostic stages of cancer [214,215].”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [214]
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- Authors
- Shehada, N., Brönstrup, G., Funka, K., Christiansen, S., Leja, M., & Haick, H.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Max Planck Institute for the Science of Light (DE)
- Faculty of Medicine, University of Latvia, LV1006 Riga, Latvia
- Corresponding author
- Haick, Hossam
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-12-18
- Volume
- 15
- Issue
- 2
- Pages
- 1288-1295
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2318925497
- Cited by
- 255
- References
- 34
- Citations by year
- 2026: 3 · 2025: 17 · 2024: 18 · 2023: 14 · 2022: 25 · 2021: 28 · 2020: 26 · 2019: 16 · 2018: 29 · 2017: 25 · 2016: 37 · 2015: 17
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- EU FP7 Health Program (258868)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
- Physical Sciences › Engineering › Biomedical Engineering › Nanowire Synthesis and Applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Gas Sensing Nanomaterials and Sensors
- Keywords
- silicon nanowire transistors, volatile organic compounds, exhaled breath, gastric cancer, cancer diagnosis, non-invasive diagnosis, portable gas sensor
- MeSH terms
- Breath Tests, Humans, Neoplasms, Silicon, Nanowires, Volatile Organic Compounds, Limit of Detection
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