Self-Healable Sensors Based Nanoparticles for Detecting Physiological Markers via Skin and Breath: Toward Disease Prevention via Wearable Devices
Abstract
Flexible and wearable electronic sensors are useful for the early diagnosis and monitoring of an individual's health state. Sampling of volatile organic compounds (VOCs) derived from human breath/skin or monitoring abrupt changes in heart-beat/breath rate should allow noninvasive monitoring of disease states at an early stage. Nevertheless, for many reported wearable sensing devices, interaction with the human body leads incidentally to unavoidable scratches and/or mechanical cuts and bring about malfunction of these devices. We now offer proof-of-concept of nanoparticle-based flexible sensor arrays with fascinating self-healing abilities. By integrating a self-healable polymer substrate with 5 kinds of functionalized gold nanoparticle films, a sensor array gives a fast self-healing (<3 h) and attractive healing efficiency in both the substrate and sensing films. The proposed platform was used in sensing pressure variation and 11 kinds of VOCs. The sensor array had satisfactory sensitivity, a low detection limit, and promising discrimination features in monitoring both of VOCs and pressure variation, even after full healing. These results presage a new type of smart sensing device, with a desirable performance in the possible detection and/or clinical application for a number of different purposes.
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AuNP films functionalized by 5 kinds of ligands were used to detect 11 different kinds of VOCs emitted from breath or skin.
“AuNP films functionized by 5 kinds of ligands were used to detect 11 different kinds of VOCs emitted from breath or skin.”
From Nanomaterial-Enabled Wearable Sensors for Healthcare (2018) · cites this paper as [198]
A AuNP resistive pressure sensor was used to measure the heart beat and breath rate from the skin deformations.
“A AuNP resistive pressure sensor was used to measure the heart beat and breath rate from the skin deformations.”
From Nanomaterial-Enabled Wearable Sensors for Healthcare (2018) · cites this paper as [198]
Jin et al. integrated a type of self-healing polymer with a functionalized AuNP sensor array to detect VOCs in human breath or on skin and monitor heart beat and breath rate.
“Jin et al. integrated a type of self-healing polymer with a functionalized AuNP sensor array to detect VOCs in human breath or on skin and monitor heart beat and breath rate.[198]”
From Nanomaterial-Enabled Wearable Sensors for Healthcare (2018) · cites this paper as [198]
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- Authors
- Jin, H., Huynh, T.-P., & Haick, H.
- Affiliations
- Ningbo University (CN)
- Corresponding author
- Haick, Hossam
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-06-27
- Volume
- 16
- Issue
- 7
- Pages
- 4194-4202
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2472559814
- Cited by
- 167
- References
- 47
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 11 · 2023: 11 · 2022: 22 · 2021: 16 · 2020: 19 · 2019: 22 · 2018: 29 · 2017: 19 · 2016: 4
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bill and Melinda Gates Foundation (OPP1109493)
- National Natural Science Foundation of China (61301050)
- Educational Commission of Zhejiang Province (Y201326606)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Nanomaterials and Printing Technologies
- Keywords
- wearable sensors, flexible electronics, gold nanoparticle films, volatile organic compounds, breath analysis, skin monitoring, pressure sensing, non-invasive disease monitoring, sensor arrays
- MeSH terms
- Wearable Electronic Devices, Breath Tests, Gold, Humans, Skin, Metal Nanoparticles, Volatile Organic Compounds
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