The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mesoscale Nanoparticles Selectively Target the Renal Proximal Tubule Epithelium
Open accessAbstract
We synthesized "mesoscale" nanoparticles, approximately 400 nm in diameter, which unexpectedly localized selectively in renal proximal tubules and up to 7 times more efficiently in the kidney than other organs. Although nanoparticles typically localize in the liver and spleen, modulating their size and opsonization potential allowed for stable targeting of the kidneys through a new proposed uptake mechanism. Applying this kidney targeting strategy, we anticipate use in the treatment of renal disease and the study of renal physiology.
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Factors affecting the clearance and biodistribution of polymeric nanoparticles
Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699
Formulation of functionalized PLGA-PEG Nanoparticles for in vivo targeted drug delivery
Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Langer, R., & Farokhzad, O. C. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.047 · Cited by 1,273
Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA-mPEG nanoparticles
Panagi, Z., Beletsi, A., Evangelatos, G., Livaniou, E., Ithakissios, D. S., & Avgoustakis, K. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00676-7 · Cited by 215
Cited by
Targeted drug delivery strategies for precision medicines
Manzari, M. T., Shamay, Y., Kiguchi, H., Rosen, N., Scaltriti, M., & Heller, D. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-020-00269-6 · Cited by 1,183
Self-citationTransport and interactions of nanoparticles in the kidneys
Du, B., Yu, M., & Zheng, J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0038-3 · Cited by 649
Xu, M., Qi, Y., Liu, G., Song, Y., Jiang, X., & Du, B. (2023) · ACS Nano · doi:10.1021/acsnano.3c05853 · Cited by 632
DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury
Jiang, D., Ge, Z., Im, H.-J., England, C. G., Ni, D., Hou, J., Zhang, L., Kutyreff, C. J., Yan, Y., Liu, Y., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0317-8 · Cited by 447
Yin, T., Fan, Q., Hu, F., Ma, X., Yin, Y., Wang, B., Kuang, L., Hu, X., Xu, B., & Wang, Y. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c01863 · Cited by 147
Metadata
- Authors
- Williams, R. M., Shah, J., Ng, B. D., Minton, D. R., Gudas, L. J., Park, C. Y., & Heller, D. A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-03-26
- Volume
- 15
- Issue
- 4
- Pages
- 2358-2364
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1991581690
- Cited by
- 185
- References
- 4
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- green
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