Plasmonic Intravascular Photoacoustic Imaging for Detection of Macrophages in Atherosclerotic Plaques
Abstract
To detect macrophages in atherosclerotic plaques, plasmonic gold nanoparticles are introduced as a contrast agent for intravascular photoacoustic imaging. The phantom and ex vivo tissue studies show that the individual spherical nanoparticles, resonant at 530 nm wavelength, produce a weak photoacoustic signal at 680 nm wavelength while photoacoustic signal from nanoparticles internalized by macrophages is very strong due to the plasmon resonance coupling effect. These results suggest that intravascular photoacoustic imaging can assess the macrophage-mediated aggregation of nanoparticles and therefore identify the presence and the location of nanoparticles associated with macrophage-rich atherosclerotic plaques.
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Imaging centrally located blood vessels with optical techniques and ultrasound has necessitated development of invasive catheter-based imaging systems.
“Therefore, imaging centrally located blood vessels with optical techniques and ultrasound has necessitated the development of invasive catheter-based imaging systems153.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [153]
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- Authors
- Wang, B., Yantsen, E., Larson, T., Karpiouk, A. B., Sethuraman, S., Su, J. L., Sokolov, K., & Emelianov, S. Y.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Emelianov, Stanislav Y.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-10-10
- Volume
- 9
- Issue
- 6
- Pages
- 2212-2217
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2075244150
- Cited by
- 208
- References
- 35
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 8 · 2023: 4 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 12 · 2018: 12 · 2017: 14 · 2016: 22 · 2015: 9 · 2014: 19 · 2013: 15 · 2012: 19
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL084076, R21HL084076)
- National Institute of Biomedical Imaging and Bioengineering (R21EB004963, EB 004963)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- intravascular photoacoustic imaging, plasmonic gold nanoparticles, macrophages, atherosclerotic plaque, nanoparticle contrast agents, plasmon resonance, nanoparticle uptake, nanoparticle aggregation
- MeSH terms
- Acoustics, Animals, Blood Vessels, Contrast Media, Gold, Macrophages, Phantoms, Imaging, Surface Plasmon Resonance, Atherosclerosis, Mice, Metal Nanoparticles
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