Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography
Abstract
Sudden fibrous cap disruption of 'high-risk' atherosclerotic plaques can trigger the formation of an occlusive thrombus in coronary arteries, causing acute coronary syndromes. High-risk atherosclerotic plaques are characterized by their specific cellular and biological content (in particular, a high density of macrophages), rather than by their impact on the vessel lumen. Early identification of high-risk plaques may be useful for preventing ischemic events. One major hurdle in detecting high-risk atherosclerotic plaques in coronary arteries is the lack of an imaging modality that allows for the identification of atherosclerotic plaque composition with high spatial and temporal resolutions. Here we show that macrophages in atherosclerotic plaques of rabbits can be detected with a clinical X-ray computed tomography (CT) scanner after the intravenous injection of a contrast agent formed of iodinated nanoparticles dispersed with surfactant. This contrast agent may become an important adjunct to the clinical evaluation of coronary arteries with CT.
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N1177 has been successfully tested in atherosclerotic animal model for detection of macrophage accumulation in arterial walls.
“An iodinated aroyloxy ester, N1177, has been successfully tested in an atherosclerotic animal model for the detection of macrophage accumulation in arterial walls.151”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [151]
Hyafil et al. published the first example of CT-based molecular imaging using iodinated nanoparticles for detection of macrophages in a rabbit model, showing marked signal enhancement 2 hours after injection.
“Hyafil et al.141 published the first example of CT-based molecular imaging using iodinated nanoparticles for the detection of macrophages in a rabbit model of atherosclerotic plaques, showing a marked signal enhancement 2 hours after injection of the iodinated nanoparticles (FIG. 5f).”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [141]
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- Authors
- Hyafil, F., Cornily, J.-C., Feig, J. E., Gordon, R., Vucic, E., Amirbekian, V., Fisher, E. A., Fuster, V., Feldman, L. J., & Fayad, Z. A.
- Affiliations
- Inserm (FR)
- Icahn School of Medicine at Mount Sinai (US)
- New York University (US)
- Mount Sinai Hospital (US)
- Corresponding author
- Fayad, Zahi A
- Venue
- Nature Medicine
- Published
- 2007-04-08
- Volume
- 13
- Issue
- 5
- Pages
- 636-641
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2065182922
- Cited by
- 467
- References
- 36
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 20 · 2021: 14 · 2020: 21 · 2019: 17 · 2018: 20 · 2017: 15 · 2016: 26 · 2015: 28 · 2014: 36 · 2013: 29 · 2012: 41
- FWCI
- 31.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fédération Française de Cardiologie
- Centers for Disease Control and Prevention (R01 HK71021)
- National Heart, Lung, and Blood Institute (R01HL078667, R01 HL 78667)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Physical Sciences › Engineering › Biomedical Engineering › Advanced X-ray and CT Imaging
- Keywords
- surfactant-stabilized nanoparticles, coronary artery disease, acute coronary syndrome, fibrous cap rupture, non-invasive imaging, rabbit model
- MeSH terms
- Contrast Media, Coronary Vessels, Humans, Iodine, Kinetics, Macrophages, Microscopy, Electron, Tomography, X-Ray Computed, Atherosclerosis, Nanoparticles
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