The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Engineering of Hetero-Functional Gold Nanorods for the in vivo Molecular Targeting of Breast Cancer Cells
Open accessAbstract
A novel technique is described to functionalize gold nanorods (GNRs) allowing for in vivo targeting of breast cancer tumors grown in athymic nude mice. GNRs were functionalized by covalent attachment of Herceptin (HER), a monoclonal antibody that enables molecular recognition of breast cancer cells expressing highly specific tumor associated antigens, and poly(ethylene glycol) (PEG) which obscures particles against the reticuloendothelial system in the body. The stability and functionality of fabricated particles (Her-PEG GNRs) were demonstrated in vitro in the presence of blood and then in vivo in nude mice model for breast cancer. The results demonstrate successful tumor accumulation of functionalized gold nanorods within HER2/neu overexpressing breast tumors in tumor-bearing nude mice and support the notions that GNRs can be used for molecular imaging of tumor.
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Cites
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells
Chang, C. J., Chiu, J. H., Tseng, L. M., Chang, C. H., Chien, T. M., Wu, C. W., & Lui, W. Y. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01676.x · Cited by 80
Cited by
Khlebtsov, N., & Dykman, L. (2011) · Chem. Soc. Rev. · doi:10.1039/c0cs00018c · Cited by 1,584
Sharifi, S., Behzadi, S., Laurent, S., Laird Forrest, M., Stroeve, P., & Mahmoudi, M. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15188f · Cited by 1,460
Gold Nanoparticles for Photothermal Cancer Therapy
Vines, J. B., Yoon, J.-H., Ryu, N.-E., Lim, D.-J., & Park, H. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00167 · Cited by 906
A New Era for Cancer Treatment: Gold‐Nanoparticle‐Mediated Thermal Therapies
Kennedy, L. C., Bickford, L. R., Lewinski, N. A., Coughlin, A. J., Hu, Y., Day, E. S., West, J. L., & Drezek, R. A. (2011) · Small · doi:10.1002/smll.201000134 · Cited by 885
Chandrakala, V., Aruna, V., & Angajala, G. (2022) · Emergent Materials · doi:10.1007/s42247-021-00335-x · Cited by 768
Metadata
- Authors
- Eghtedari, M., Liopo, A. V., Copland, J. A., Oraevsky, A. A., & Motamedi, M.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-01-14
- Volume
- 9
- Issue
- 1
- Pages
- 287-291
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2036969572
- Cited by
- 226
- References
- 3
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
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