The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion
Open accessAbstract
We herein present a novel platform of well-controlled ordered and disordered nanopatterns positioned with a cyclic peptide of arginine-glycine-aspartic acid (RGD) on a bioinert poly(ethylene glycol) background, to study whether the nanoscopic order of spatial patterning of the integrin-specific ligands influences osteoblast adhesion. This is the first time that the nanoscale order of RGD ligand patterns was varied quantitatively, and tested for its impact on the adhesion of tissue cells. Our findings reveal that integrin clustering and such adhesion induced by RGD ligands is dependent on the local order of ligand arrangement on a substrate when the global average ligand spacing is larger than 70 nm; i.e., cell adhesion is "turned off" by RGD nanopattern order and "turned on" by the RGD nanopattern disorder if operating at this range of interligand spacing.
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Cited by
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Polyethylene glycol (PEG): A versatile polymer for pharmaceutical applications
D’souza, A. A., & Shegokar, R. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1182485 · Cited by 1,282
Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
Dalby, M. J., Gadegaard, N., & Oreffo, R. O. C. (2014) · Nature Materials · doi:10.1038/nmat3980 · Cited by 1,082
Materials as stem cell regulators
Murphy, W. L., McDevitt, T. C., & Engler, A. J. (2014) · Nature Materials · doi:10.1038/nmat3937 · Cited by 947
Ren, X., Feng, Y., Guo, J., Wang, H., Li, Q., Yang, J., Hao, X., Lv, J., Ma, N., & Li, W. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00483c · Cited by 573
Metadata
- Authors
- Huang, J., Gräter, S. V., Corbellini, F., Rinck, S., Bock, E., Kemkemer, R., Kessler, H., Ding, J., & Spatz, J. P.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-02-10
- Volume
- 9
- Issue
- 3
- Pages
- 1111-1116
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1977569147
- Cited by
- 543
- References
- 2
- FWCI
- 26.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, J., Gräter, S. V., Corbellini, F., Rinck, S., Bock, E., Kemkemer, R., Kessler, H., Ding, J., & Spatz, J. P. (2009). Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion. Nano Letters. https://doi.org/10.1021/nl803548b
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