The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cytotoxicity Effects of Graphene and Single-Wall Carbon Nanotubes in Neural Phaeochromocytoma-Derived PC12 Cells
Abstract
Graphitic nanomaterials such as graphene layers (G) and single-wall carbon nanotubes (SWCNT) are potential candidates in a large number of biomedical applications. However, little is known about the effects of these nanomaterials on biological systems. Here we show that the shape of these materials is directly related to their induced cellular toxicity. Both G and SWCNT induce cytotoxic effects, and these effects are concentration- and shape-dependent. Interestingly, at low concentrations, G induced stronger metabolic activity than SWCNT, a trend that reversed at higher concentrations. Lactate dehydrogenase levels were found to be significantly higher for SWCNT as compared to the G samples. Moreover, reactive oxygen species were generated in a concentration- and time-dependent manner after exposure to G, indicating an oxidative stress mechanism. Furthermore, time-dependent caspase 3 activation after exposure to G (10 microg/mL) shows evidence of apoptosis. Altogether these studies suggest different biological activities of the graphitic nanomaterials, with the shape playing a primary role.
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Cites
Graphene-based composite materials
Stankovich, S., Dikin, D. A., Dommett, G. H. B., Kohlhaas, K. M., Zimney, E. J., Stach, E. A., Piner, R. D., Nguyen, S. T., & Ruoff, R. S. (2006) · Nature · doi:10.1038/nature04969 · Cited by 12,922
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Graphene-based nanomaterials for drug delivery and tissue engineering
Goenka, S., Sant, V., & Sant, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.017 · Cited by 1,311
Nanotoxicity of Graphene and Graphene Oxide
Seabra, A. B., Paula, A. J., de Lima, R., Alves, O. L., & Durán, N. (2014) · Chemical Research in Toxicology · doi:10.1021/tx400385x · Cited by 893
A Review of Organic and Inorganic Biomaterials for Neural Interfaces
Fattahi, P., Yang, G., Kim, G., & Abidian, M. R. (2014) · Advanced Materials · doi:10.1002/adma.201304496 · Cited by 580
Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Toxicity assessment of nanomaterials: methods and challenges
Dhawan, A., & Sharma, V. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3996-x · Cited by 466
Metadata
- Authors
- Zhang, Y., Ali, S. F., Dervishi, E., Xu, Y., Li, Z., Casciano, D., & Biris, A. S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-05-18
- Volume
- 4
- Issue
- 6
- Pages
- 3181-3186
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2017581710
- Cited by
- 1,155
- References
- 1
- FWCI
- 39.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, Y., Ali, S. F., Dervishi, E., Xu, Y., Li, Z., Casciano, D., & Biris, A. S. (2010). Cytotoxicity Effects of Graphene and Single-Wall Carbon Nanotubes in Neural Phaeochromocytoma-Derived PC12 Cells. ACS Nano. https://doi.org/10.1021/nn1007176
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