Cited by 580Neuroscience and Neural EngineeringConducting polymers and applicationsElectrochemical sensors and biosensors

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

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Fattahi, Pouria, Yang, Guang, Kim, Gloria, Abidian, Mohammad Reza·2014·Advanced Materials

Abstract

Recent advances in nanotechnology have generated wide interest in applying nanomaterials for neural prostheses. An ideal neural interface should create seamless integration into the nervous system and performs reliably for long periods of time. As a result, many nanoscale materials not originally developed for neural interfaces become attractive candidates to detect neural signals and stimulate neurons. In this comprehensive review, an overview of state‐of‐the‐art microelectrode technologies provided first, with focus on the material properties of these microdevices. The advancements in electro­active nanomaterials are then reviewed, including conducting polymers, carbon nanotubes, graphene, silicon nanowires, and hybrid organic‐inorganic nanomaterials, for neural recording, stimulation, and growth. Finally, technical and scientific challenges are discussed regarding biocompatibility, mechanical mismatch, and electrical properties faced by these nanomaterials for the development of long‐lasting functional neural interfaces.

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Authors
Fattahi, P., Yang, G., Kim, G., & Abidian, M. R.
Affiliations
Pennsylvania State University (US)
Corresponding author
Abidian, Mohammad Reza
Venue
Advanced Materials
Publisher
Wiley
Published
2014-02-21
Volume
26
Issue
12
Pages
1846-1885
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W2043435803
Cited by
580
References
429
Citations by year
2026: 22 · 2025: 43 · 2024: 39 · 2023: 48 · 2022: 44 · 2021: 68 · 2020: 41 · 2019: 68 · 2018: 54 · 2017: 70 · 2016: 37 · 2015: 39 · 2014: 7
FWCI
5.81
Type
journal article
Language
en
Open access
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS087224)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
Keywords
neural interfaces, neural prostheses, microelectrodes, conducting polymers, carbon nanotubes, graphene, silicon nanowires, organic-inorganic hybrid materials, neural recording, neurostimulation, biocompatibility, mechanical mismatch
MeSH terms
Animals, Biocompatible Materials, Humans, Microelectrodes, Neurons, Nanostructures, Neural Prostheses

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