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Porous Silicon Nanoparticle Photosensitizers for Singlet Oxygen and Their Phototoxicity against Cancer Cells
Open accessAbstract
Porous Si nanoparticles, prepared from electrochemically etched single crystal Si wafers, function as photosensitizers to generate (1)O(2) in ethanol and in aqueous media. The preparation conditions for the porous Si nanoparticles were optimized to maximize (1) the yield of material; (2) its quantum yield of (1)O(2) production; and (3) its in vitro degradation properties. The optimal formulation was determined to consist of nanoparticles 146 ± 7 nm in diameter, with nominal pore sizes of 12 ± 4 nm. The quantum yield for (1)O(2) production is 0.10 ± 0.02 in ethanol and 0.17 ± 0.01 in H(2)O. HeLa or NIH-3T3 cells treated with 100 μg/mL porous Si nanoparticles and exposed to 60 J/cm(2) white light (infrared filtered, 100 mW/cm(2) for 10 min) exhibit ∼45% cell death, while controls containing no nanoparticles show 10% or 25% cell death, respectively. The dark control experiment yields <10% cytotoxicity for either cell type.
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Cited by
Photodynamic therapy – mechanisms, photosensitizers and combinations
Kwiatkowski, S., Knap, B., Przystupski, D., Saczko, J., Kędzierska, E., Knap-Czop, K., Kotlińska, J., Michel, O., Kotowski, K., & Kulbacka, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.049 · Cited by 2,173
Photosensitizers for Photodynamic Therapy
Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900132 · Cited by 1,081
Ultrathin Black Phosphorus Nanosheets for Efficient Singlet Oxygen Generation
Wang, H., Yang, X., Shao, W., Chen, S., Xie, J., Zhang, X., Wang, J., & Xie, Y. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b06025 · Cited by 1,041
Xu, S., Yuan, Y., Cai, X., Zhang, C.-J., Hu, F., Liang, J., Zhang, G., Zhang, D., & Liu, B. (2015) · Chemical Science · doi:10.1039/c5sc01733e · Cited by 530
Gong, Z., & Dai, Z. (2021) · Advanced Science · doi:10.1002/advs.202002178 · Cited by 320
Metadata
- Authors
- Xiao, L., Gu, L., Howell, S. B., & Sailor, M. J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-04-06
- Volume
- 5
- Issue
- 5
- Pages
- 3651-3659
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2028539204
- Cited by
- 305
- References
- 0
- FWCI
- 16.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Xiao, L., Gu, L., Howell, S. B., & Sailor, M. J. (2011). Porous Silicon Nanoparticle Photosensitizers for Singlet Oxygen and Their Phototoxicity against Cancer Cells. ACS Nano. https://doi.org/10.1021/nn1035262
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