The DOI matches its Crossref record; 220 of the 220 references it cites were found in a registry or an index.
Photosensitizers for Photodynamic Therapy
Abstract
As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in the presence of oxygen (O 2). However, further advancements including tumor selectivity and ROS generation efficiency are still required. Substantial efforts are devoted to design and synthesize smart PSs with optimized properties for achieving a desirable therapeutic efficacy. This review summarizes the recent progress in developing intelligent PSs for efficient PDT, ranging from single molecules to delicate nanomaterials. The strategies to improve ROS generation through optimizing photoinduced electron transfer and energy transfer processes of PSs are highlighted. Moreover, the approaches that combine PDT with other therapeutics (e.g., chemotherapy, photothermal therapy, and radiotherapy) and the targeted delivery in cancer cells or tumor tissue are introduced. The main challenges for the clinical application of PSs are also discussed.
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Cites
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Self-citation
Cited by
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Natural Photosensitizers in Antimicrobial Photodynamic Therapy
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Stimuli responsive nanosonosensitizers for sonodynamic therapy
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Metadata
- Authors
- Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2019-05-08
- Volume
- 8
- Issue
- 13
- Pages
- e1900132-e1900132
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2944794168
- Cited by
- 1,081
- References
- 220
- FWCI
- 71.98
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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