The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular Engineering
Abstract
A facile in situ supramolecular assembly and modular modification of biocompatible hydrogels were demonstrated using cucurbit[6]uril-conjugated hyaluronic acid (CB[6]-HA), diaminohexane-conjugated HA (DAH-HA), and tags-CB[6] for cellular engineering applications. The strong and selective host-guest interaction between CB[6] and DAH made possible the supramolecular assembly of CB[6]/DAH-HA hydrogels in the presence of cells. Then, the 3D environment of CB[6]/DAH-HA hydrogels was modularly modified by the simple treatment with various multifunctional tags-CB[6]. Furthermore, we could confirm in situ formation of CB[6]/DAH-HA hydrogels under the skin of nude mice by sequential subcutaneous injections of CB[6]-HA and DAH-HA solutions. The fluorescence of modularly modified fluorescein isothiocyanate (FITC)-CB[6] in the hydrogels was maintained for up to 11 days, reflecting the feasibility to deliver the proper cues for cellular proliferation and differentiation in the body. Taken together, CB[6]/DAH-HA hydrogels might be successfully exploited as a 3D artificial extracellular matrix for various tissue engineering applications.
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Citations
Cites
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864
Self-citationLutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Cited by
Cucurbituril-Based Molecular Recognition
Barrow, S. J., Kasera, S., Rowland, M. J., del Barrio, J., & Scherman, O. A. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00341 · Cited by 1,898
Webber, M. J., Appel, E. A., Meijer, E. W., & Langer, R. (2016) · Nature Materials · doi:10.1038/nmat4474 · Cited by 1,605
Supramolecular polymeric hydrogels
Appel, E. A., del Barrio, J., Loh, X. J., & Scherman, O. A. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35264h · Cited by 1,159
The design of reversible hydrogels to capture extracellular matrix dynamics
Rosales, A. M., & Anseth, K. S. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2015.12 · Cited by 772
Xia, D., Wang, P., Ji, X., Khashab, N. M., Sessler, J. L., & Huang, F. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00839 · Cited by 734
Metadata
- Authors
- Park, K. M., Yang, J.-A., Jung, H., Yeom, J., Park, J. S., Park, K.-H., Hoffman, A. S., Hahn, S. K., & Kim, K.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-03-15
- Volume
- 6
- Issue
- 4
- Pages
- 2960-2968
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2315934024
- Cited by
- 239
- References
- 2
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Park, K. M., Yang, J.-A., Jung, H., Yeom, J., Park, J. S., Park, K.-H., Hoffman, A. S., Hahn, S. K., & Kim, K. (2012). In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular Engineering. ACS Nano. https://doi.org/10.1021/nn204123p
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