The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.
The design of reversible hydrogels to capture extracellular matrix dynamics
Open accessAbstract
The extracellular matrix (ECM) is a dynamic environment that constantly provides physical and chemical cues to embedded cells. Much progress has been made in engineering hydrogels that can mimic the ECM, but hydrogel properties are, in general, static. To recapitulate the dynamic nature of the ECM, many reversible chemistries have been incorporated into hydrogels to regulate cell spreading, biochemical ligand presentation and matrix mechanics. For example, emerging trends include the use of molecular photoswitches or biomolecule hybridization to control polymer chain conformation, thereby enabling the modulation of the hydrogel between two states on demand. In addition, many non-covalent, dynamic chemical bonds have found increasing use as hydrogel crosslinkers or tethers for cell signalling molecules. These reversible chemistries will provide greater temporal control of adhered cell behaviour, and they allow for more advanced in vitro models and tissue-engineering scaffolds to direct cell fate. Tuning the reversible chemistries in hydrogels makes it possible to mimic the dynamic nature of the extracellular matrix. Various chemistries have been incorporated to regulate cell spreading, biochemical presentation and matrix mechanics.
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Moroni, L., Burdick, J. A., Highley, C., Lee, S. J., Morimoto, Y., Takeuchi, S., & Yoo, J. J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0006-y · Cited by 753
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Metadata
- Authors
- Rosales, A. M., & Anseth, K. S.
- Venue
- Nature Reviews Materials
- Published
- 2016-02-02
- Volume
- 1
- Issue
- 2
- ISSN
- 2058-8437 (ISSN-L)
- OpenAlex
- W2315234938
- Cited by
- 772
- References
- 175
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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