The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells
Open accessAbstract
Human embryonic stem cells (hESCs) have great potentials for future cell-based therapeutics. However, their mechanosensitivity to biophysical signals from the cellular microenvironment is not well characterized. Here we introduced an effective microfabrication strategy for accurate control and patterning of nanoroughness on glass surfaces. Our results demonstrated that nanotopography could provide a potent regulatory signal over different hESC behaviors, including cell morphology, adhesion, proliferation, clonal expansion, and self-renewal. Our results indicated that topological sensing of hESCs might include feedback regulation involving mechanosensory integrin-mediated cell-matrix adhesion, myosin II, and E-cadherin. Our results also demonstrated that cellular responses to nanotopography were cell-type specific, and as such, we could generate a spatially segregated coculture system for hESCs and NIH/3T3 fibroblasts using patterned nanorough glass surfaces.
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Citations
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
Environmental sensing through focal adhesions
Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543
Local force and geometry sensing regulate cell functions
Vogel, V., & Sheetz, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1890 · Cited by 2,328 · cited 2×
“signaling is closely related to its molecular arrangement and dynamic organization, which can be affected directly by local nanotopological cues.(2) To investigate the likely involvement of integrin-”
Substrate topography shapes cell function
Kulangara, K., & Leong, K. W. (2009) · Soft Matter · doi:10.1039/b910132m · Cited by 145
Non-muscle myosin II regulates survival threshold of pluripotent stem cells
Walker, A., Su, H., Conti, M. A., Harb, N., Adelstein, R. S., & Sato, N. (2010) · Nature Communications · doi:10.1038/ncomms1074 · Cited by 87
Cited by
Edmondson, R., Broglie, J. J., Adcock, A. F., & Yang, L. (2014) · ASSAY and Drug Development Technologies · doi:10.1089/adt.2014.573 · Cited by 2,515
Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
Dalby, M. J., Gadegaard, N., & Oreffo, R. O. C. (2014) · Nature Materials · doi:10.1038/nmat3980 · Cited by 1,082
3D biofabrication strategies for tissue engineering and regenerative medicine
Bajaj, P., Schweller, R. M., Khademhosseini, A., West, J. L., & Bashir, R. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-105155 · Cited by 632
Physical Cues of Biomaterials Guide Stem Cell Differentiation Fate
Higuchi, A., Ling, Q.-D., Chang, Y., Hsu, S.-T., & Umezawa, A. (2013) · Chemical Reviews · doi:10.1021/cr300426x · Cited by 458
Bioengineering strategies to accelerate stem cell therapeutics
Madl, C. M., Heilshorn, S. C., & Blau, H. M. (2018) · Nature · doi:10.1038/s41586-018-0089-z · Cited by 425
Metadata
- Authors
- Chen, W., Villa-Diaz, L. G., Sun, Y., Weng, S., Kim, J. K., Lam, R. H. W., Han, L., Fan, R., Krebsbach, P. H., & Fu, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-16
- Volume
- 6
- Issue
- 5
- Pages
- 4094-4103
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2110282630
- Cited by
- 350
- References
- 7
- FWCI
- 17.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, W., Villa-Diaz, L. G., Sun, Y., Weng, S., Kim, J. K., Lam, R. H. W., Han, L., Fan, R., Krebsbach, P. H., & Fu, J. (2012). Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells. ACS Nano. https://doi.org/10.1021/nn3004923
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
