The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery
Abstract
The therapeutic effectiveness of chemotherapy is optimal only when tumor cells are subjected to a maximum drug exposure. To increase the intratumoral drug concentration and thus the efficacy of chemotherapy, a thermoresponsive bubble-generating liposomal system is proposed for triggering localized extracellular drug delivery. The key component of this liposomal formulation is the encapsulated ammonium bicarbonate (ABC), which is used to create the transmembrane gradient needed for a highly efficient encapsulation of doxorubicin (DOX). At an elevated temperature (42 °C), decomposition of ABC generates CO(2) bubbles, creating permeable defects in the lipid bilayer that rapidly release DOX and instantly increase the drug concentration locally. Because the generated CO(2) bubbles are hyperechogenic, they also enhance ultrasound imaging. Consequently, this new liposomal system encapsulated with ABC may also provide an ability to monitor a temperature-controlled drug delivery process.
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Doxil® — The first FDA-approved nano-drug: Lessons learned
Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
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Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Sahandi Zangabad, P., Rahighi, R., Moosavi Basri, S. M., Mirshekari, H., Amiri, M., Shafaei Pishabad, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,519
Cancer nanomedicine: A review of recent success in drug delivery
Tran, S., DeGiovanni, P., Piel, B., & Rai, P. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0175-0 · Cited by 879
Mechanisms of drug release in nanotherapeutic delivery systems
Wong, P. T., & Choi, S. K. (2015) · Chemical Reviews · doi:10.1021/cr5004634 · Cited by 507
Metadata
- Authors
- Chen, K.-J., Liang, H.-F., Chen, H.-L., Wang, Y., Cheng, P.-Y., Liu, H.-L., Xia, Y., & Sung, H.-W.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-12-20
- Volume
- 7
- Issue
- 1
- Pages
- 438-446
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2046551236
- Cited by
- 279
- References
- 2
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, K.-J., Liang, H.-F., Chen, H.-L., Wang, Y., Cheng, P.-Y., Liu, H.-L., Xia, Y., & Sung, H.-W. (2013). A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery. ACS Nano. https://doi.org/10.1021/nn304474j
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