The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Facing the Truth about Nanotechnology in Drug Delivery
Open accessAbstract
Nanotechnology in drug delivery has been manifested into nanoparticles that can have unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors. Numerous nanoparticle formulations have been designed and tested to great effect in small animal models, but the translation of the small animal results to clinical success has been limited. Successful translation requires revisiting the meaning of nanotechnology in drug delivery, understanding the limitations of nanoparticles, identifying the misconceptions pervasive in the field, and facing inconvenient truths. Nanoparticle approaches can have real impact in improving drug delivery by focusing on the problems at hand, such as enhancing their drug loading capacity, affinity to target cells, and spatiotemporal control of drug release.
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Cites
Doxil® — The first FDA-approved nano-drug: Lessons learned
Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792
Drug nanocrystals: in vivo performances.
Gao, L., Liu, G., Ma, J., Wang, X., Zhou, L., & Li, X. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.013 · Cited by 347
Development of an in Vitro 3D Tumor Model to Study Therapeutic Efficiency of an Anticancer Drug
Shin, C. S., Kwak, B., Han, B., & Park, K. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300595a · Cited by 135
Self-citation
Cited by
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002
Analysis of nanoparticle delivery to tumours
Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218
In vitro and ex vivo strategies for intracellular delivery
Stewart, M. P., Sharei, A., Ding, X., Sahay, G., Langer, R., & Jensen, K. F. (2016) · Nature · doi:10.1038/nature19764 · Cited by 885
Emerging Applications of Nanotechnology in Healthcare and Medicine
Malik, S., Muhammad, K., & Waheed, Y. (2023) · Molecules · doi:10.3390/molecules28186624 · Cited by 610
Biological interactions of carbon-based nanomaterials: From coronation to degradation
Bhattacharya, K., Mukherjee, S. P., Gallud, A., Burkert, S. C., Bistarelli, S., Bellucci, S., Bottini, M., Star, A., & Fadeel, B. (2016) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.11.011 · Cited by 402
Metadata
- Authors
- Park, K.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-09-24
- Volume
- 7
- Issue
- 9
- Pages
- 7442-7447
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2067796149
- Cited by
- 544
- References
- 3
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Park, K. (2013). Facing the Truth about Nanotechnology in Drug Delivery. ACS Nano. https://doi.org/10.1021/nn404501g
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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