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Engineering a Hollow Nanocontainer Platform with Multifunctional Molecular Machines for Tumor-Targeted Therapy in Vitro and in Vivo
Abstract
In order to selectively target malignant cells and eliminate severe side effects of conventional chemotherapy, biocompatible and redox-responsive hollow nanocontainers with tumor specificity were fabricated. The mechanized nanocontainers were achieved by anchoring mechanically interlocked molecules, i.e., [2]rotaxanes, onto the orifices of hollow mesoporous silica nanoparticles via disulfide bonds as intermediate linkers for intracellular glutathione-triggered drug release. The [2]rotaxane employed was mainly composed of U.S. Food and Drug Administration approved tetraethylene glycol chains, α-cyclodextrin, and folic acid. In this study, folate groups on the mechanized hollow nanocontainers act as both the tumor-targeting agents and stoppers of the [2]rotaxanes. Detailed investigations showed that anticancer drug doxorubicin loaded mechanized nanocontainers could selectively induce the apoptosis and death of tumor cells. The drug-loaded nanocontainers enhanced the targeting capability to tumor tissues in vitro and inhibited the tumor growth with minimal side effects in vivo. The present controlled and targeted drug delivery system paves the way for developing the next generation of nanotherapeutics toward efficient cancer treatment.
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Cited by
Leveraging Physiology for Precision Drug Delivery
Sun, W., Hu, Q., Ji, W., Wright, G., & Gu, Z. (2017) · Physiological Reviews · doi:10.1152/physrev.00015.2016 · Cited by 169
Palanikumar, L., Choi, E. S., Cheon, J. Y., Joo, S. H., & Ryu, J. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201402755 · Cited by 150
AbouAitah, K., Swiderska-Sroda, A., Farghali, A. A., Wojnarowicz, J., Stefanek, A., Gierlotka, S., Opalinska, A., Allayeh, A. K., Ciach, T., & Lojkowski, W. (2018) · Oncotarget · doi:10.18632/oncotarget.25470 · Cited by 83
Tang, Z., Zhang, L., Wang, Y., Li, D., Zhong, Z., & Zhou, S. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.06.038 · Cited by 73
Enhanced In Vivo Radiotherapy of Breast Cancer Using Gadolinium Oxide and Gold Hybrid Nanoparticles
Nosrati, H., Salehiabar, M., Charmi, J., Yaray, K., Ghaffarlou, M., Balcioglu, E., & Ertas, Y. N. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00965 · Cited by 73
Metadata
- Authors
- Luo, Z., Ding, X., Hu, Y., Wu, S., Xiang, Y., Zeng, Y., Zhang, B., Yan, H., Zhang, H., Zhu, L., Liu, J., Li, J., Cai, K., & Zhao, Y.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-10-21
- Volume
- 7
- Issue
- 11
- Pages
- 10271-10284
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2327516562
- Cited by
- 221
- References
- 2
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Luo, Z., Ding, X., Hu, Y., Wu, S., Xiang, Y., Zeng, Y., Zhang, B., Yan, H., Zhang, H., Zhu, L., Liu, J., Li, J., Cai, K., & Zhao, Y. (2013). Engineering a Hollow Nanocontainer Platform with Multifunctional Molecular Machines for Tumor-Targeted Therapy in Vitro and in Vivo. ACS Nano. https://doi.org/10.1021/nn404676w
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