CoChat
Sign Up
Cited by 83

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Folic acid-conjugated mesoporous silica particles as nanocarriers of natural prodrugs for cancer targeting and antioxidant action

AbouAitah, Khaled, Swiderska-Sroda, Anna, Farghali, Ahmed A., Wojnarowicz, Jacek, Stefanek, Agata, Gierlotka, Stanislaw, Opalinska, Agnieszka, Allayeh, Abdou K., Ciach, Tomasz, Lojkowski, Witold·2018·Oncotarget
DOI 10.18632/oncotarget.25470PMC PMC5995188
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.18632/oncotarget.25470

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 SEM (A, C) and TEM (B, D) images of mesoporous silica nanomaterials: KCC-Calcined (A, B) and MCM-Calcined (C, D).
Figure 1 SEM (A, C) and TEM (B, D) images of mesoporous silica nanomaterials: KCC-Calcined (A, B) and MCM-Calcined (C, D).CC BY · PubMed Central
Figure 2 DSC profiles of as-synthesized (calcined) MSNs, FITC-labeled MSNs, FA-conjugated MSNs, drug-loaded FA-conjugated MSNs, and pure prodrugs
Figure 2 DSC profiles of as-synthesized (calcined) MSNs, FITC-labeled MSNs, FA-conjugated MSNs, drug-loaded FA-conjugated MSNs, and pure prodrugsCC BY · PubMed Central
Figure 3 XRD patterns of FA-conjugated MSNs, drug-loaded FA-conjugated MSNs, and physical mixtures (P.M.) materials (simple mixing of drug with MSNs)
Figure 3 XRD patterns of FA-conjugated MSNs, drug-loaded FA-conjugated MSNs, and physical mixtures (P.M.) materials (simple mixing of drug with MSNs)CC BY · PubMed Central
Figure 4 FT-IR spectra of: (A) as-synthesized (calcined) MSNs, amino-modified MSNs, and FITC-labeled MSNs (B); CR-loaded to FA-conjugated MSNs (B); QR-loaded FA-conjugated MSNs (C); and COL-loaded FA-conjugated MSNs COL-loaded to FA-conjugated MSNs (D).
Figure 4 FT-IR spectra of: (A) as-synthesized (calcined) MSNs, amino-modified MSNs, and FITC-labeled MSNs (B); CR-loaded to FA-conjugated MSNs (B); QR-loaded FA-conjugated MSNs (C); and COL-loaded FA-conjugated MSNs COL-loaded to FA-conjugated MSNs (D).CC BY · PubMed Central
Figure 5 Zeta potential measurements of: (A) as-synthesized (calcined) MSNs, amino-functionalized MSNs, FITC-labeled MSNs, and FA-conjugated MSNs (B) prodrug-loaded FA-conjugated MSNs.
Figure 5 Zeta potential measurements of: (A) as-synthesized (calcined) MSNs, amino-functionalized MSNs, FITC-labeled MSNs, and FA-conjugated MSNs (B) prodrug-loaded FA-conjugated MSNs.CC BY · PubMed Central
Figure 6 SEM images of cellular uptake of HeLa cells as a function of surface modification of MSNs after 24-h incubation time MCM-Calcined (A), KCC-Calcined (B), MCM-NH2 (C), KCC-NH2 (D), MCM-NH2-FA (E), and KCC-NH2-FA (F).
Figure 6 SEM images of cellular uptake of HeLa cells as a function of surface modification of MSNs after 24-h incubation time MCM-Calcined (A), KCC-Calcined (B), MCM-NH2 (C), KCC-NH2 (D), MCM-NH2-FA (E), and KCC-NH2-FA (F).CC BY · PubMed Central
Figure 7 Confocal laser scanning microscopy (CLSM) images of cellular uptake of HeLa cells treated with FITC (green fluorescence) dye-labeled MSNs (MCM-FITC and KCC-FITC) as a function of time The cell nucleus was stained with DAPI (blue).
Figure 7 Confocal laser scanning microscopy (CLSM) images of cellular uptake of HeLa cells treated with FITC (green fluorescence) dye-labeled MSNs (MCM-FITC and KCC-FITC) as a function of time The cell nucleus was stained with DAPI (blue).CC BY · PubMed Central
Figure 8 Confocal laser scanning microscopy (CLSM) images of intracellular and drug release in HeLa cells of different forms of CR (green fluorescence) as an anticancer prodrug as a function of time Vertical columns show free form, CR-loaded amino-functionalized MSNs (MCM-CR = denotes MCM-NH2-CR and KCC-CR = denotes KCC-NH2-CR), and CR-loaded FA-conjugated MSNs (MCM-FA-CR = denotes MCM-NH2-FA-CR and KCC-FA-CR = denotes KCC-NH2-FA-CR). The cell nucleus was stained with DAPI (blue). The release of CR prodrug can be seen by red arrows. Arrows indicate CR release after MSNs internalization.
Figure 8 Confocal laser scanning microscopy (CLSM) images of intracellular and drug release in HeLa cells of different forms of CR (green fluorescence) as an anticancer prodrug as a function of time Vertical columns show free form, CR-loaded amino-functionalized MSNs (MCM-CR = denotes MCM-NH2-CR and KCC-CR = denotes KCC-NH2-CR), and CR-loaded FA-conjugated MSNs (MCM-FA-CR = denotes MCM-NH2-FA-CR and KCC-FA-CR = denotes KCC-NH2-FA-CR). The cell nucleus was stained with DAPI (blue). The release of CR prodrug can be seen by red arrows. Arrows indicate CR release after MSNs internalization.CC BY · PubMed Central
Figure 9 In vitro cytotoxicity and biocompatibility evaluation of anticancer natural prodrugs suspended in PBS buffer against HepG2 and HeLa cancer cells for 24 h of incubation (A) Biocompatibility of calcined MSNs and amino-functionalized MSNs with concentrations up to 750 µg/ml in HepG2 cells; (B) Biocompatibility of calcined MSNs and amino-functionalized MSNs with concentrations up to 750 µg/ml in HeLa cells; (C) cytotoxicity of pure CR and its nanoformulations in HepG2 cells; (D) cytotoxicity of QR and its nanoformulations in HepG2 cells; (E) cytotoxicity of COL and its nanoformulations; and (F) cytotoxicity of pure CR and its nanoformulations in HeLa cells. Notes: Data are expressed as mean and error bars represent ± standard deviation; *p < 0.05 compared to samples under same concentration; #p < 0.05 compared to concentration of 1 µg/ml (as control).
Figure 9 In vitro cytotoxicity and biocompatibility evaluation of anticancer natural prodrugs suspended in PBS buffer against HepG2 and HeLa cancer cells for 24 h of incubation (A) Biocompatibility of calcined MSNs and amino-functionalized MSNs with concentrations up to 750 µg/ml in HepG2 cells; (B) Biocompatibility of calcined MSNs and amino-functionalized MSNs with concentrations up to 750 µg/ml in HeLa cells; (C) cytotoxicity of pure CR and its nanoformulations in HepG2 cells; (D) cytotoxicity of QR and its nanoformulations in HepG2 cells; (E) cytotoxicity of COL and its nanoformulations; and (F) cytotoxicity of pure CR and its nanoformulations in HeLa cells. Notes: Data are expressed as mean and error bars represent ± standard deviation; *p < 0.05 compared to samples under same concentration; #p < 0.05 compared to concentration of 1 µg/ml (as control).CC BY · PubMed Central
Figure 10 Molecular signaling pathways of CR-loaded FA-conjugated KCC-1 MSN (KCC-NH2-FA-CR) nanoformulation, pure CR, and KCC-NH2-FA MSNs on human HCC cells (HepG2) (A) caspase-3 activation for apoptosis pathway; (B) H2O2 intracellular expression; (C) c-MET inhibition; and (D) MCL-1 inhibition after treatments. Data are expressed as mean and error bars represent ± standard deviation; significance at p < 0.05 compared to negative control (HepG2 cells) and positive control (KCC-NH2-FA nanoparticles). In A and B, * is least significant and ** indicates high significance. In C and D, * is least significant, ** indicates medium significance and *** a very significant effect compared to KCC-NH2-FA nanoparticles as control sample.
Figure 10 Molecular signaling pathways of CR-loaded FA-conjugated KCC-1 MSN (KCC-NH2-FA-CR) nanoformulation, pure CR, and KCC-NH2-FA MSNs on human HCC cells (HepG2) (A) caspase-3 activation for apoptosis pathway; (B) H2O2 intracellular expression; (C) c-MET inhibition; and (D) MCL-1 inhibition after treatments. Data are expressed as mean and error bars represent ± standard deviation; significance at p < 0.05 compared to negative control (HepG2 cells) and positive control (KCC-NH2-FA nanoparticles). In A and B, * is least significant and ** indicates high significance. In C and D, * is least significant, ** indicates medium significance and *** a very significant effect compared to KCC-NH2-FA nanoparticles as control sample.CC BY · PubMed Central
Figure 11 Schematic representation of the prepared nano-system from preparation, internalization, and anticancer mechanism of action in human liver carcinoma (HepG2) cells This schematic shows the prodrug release into cancer cells and the main anticancer action for inducing apoptosis via activation of caspase-3 for killing HepG2 cancer cells, proposed by assistance from important signaling pathways (c-MET, MCL-1, and H2O2).
Figure 11 Schematic representation of the prepared nano-system from preparation, internalization, and anticancer mechanism of action in human liver carcinoma (HepG2) cells This schematic shows the prodrug release into cancer cells and the main anticancer action for inducing apoptosis via activation of caspase-3 for killing HepG2 cancer cells, proposed by assistance from important signaling pathways (c-MET, MCL-1, and H2O2).CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 2 references

Research works printed but not linked: 93

  1. Sechi, 2014, Targeted therapy using nanotechnology: focus on cancer, International Journal of Nanomedicine, 9, 467, 10.2147/IJN.S36654 · DOI
  2. Langer, 2007, Nanocarriers as an emerging platform for cancer therapy, Nat Nano, 2, 751, 10.1038/nnano.2007.387 · DOI · Paper page
  3. Wang, 2015, Clinical Translation of Nanomedicine, Chemical Reviews, 115, 11147, 10.1021/acs.chemrev.5b00116 · DOI
  4. Stoddart, 2011, Mechanized silica nanoparticles: a new frontier in theranostic nanomedicine, Acc Chem Res, 44, 903, 10.1021/ar200018x · DOI
  5. Cheng, 2013, Nonporous silica nanoparticles for nanomedicine application, Nano Today, 8, 290, 10.1016/j.nantod.2013.04.007 · DOI
  6. Storm, 2001, Liposomes to target the lymphatics by subcutaneous administration, Adv Drug Deliv Rev, 50, 143, 10.1016/S0169-409X(01)00154-5 · DOI
  7. Ohno, 2013, Particle-size-dependent toxicity and immunogenic activity of mesoporous silica-based adjuvants for tumor immunotherapy, Acta Biomater, 9, 7480, 10.1016/j.actbio.2013.03.031 · DOI
  8. Brieger, 2017, Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer, Nanomaterials (Basel), 7, E189, 10.3390/nano7070189 · DOI
  9. Sun, 2017, Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems, Chemical Society Reviews, 46, 6024, 10.1039/C7CS00219J · DOI
  10. Wiesner, 2011, Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma, The Journal of Clinical Investigation, 121, 2768, 10.1172/JCI45600 · DOI
  11. Wu, 2015, Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery, Journal of Nanobiotechnology, 13, 1
  12. Arcos, 2007, Mesoporous materials for drug delivery, Angew Chem Int Ed Engl, 46, 7548, 10.1002/anie.200604488 · DOI
  13. Selvaraj, 2014, Mesoporous silica nanoparticles: importance of surface modifications and its role in drug delivery, RSC Advances, 4, 14328, 10.1039/c4ra00781f · DOI
  14. Liu, 2011, Investigation of folate-conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism, Int J Nanomedicine, 6, 2023, 10.2147/IJN.S24792 · DOI
  15. Albanes, 2003, Null Association between Prostate Cancer and Serum Folate, Vitamin B6, Vitamin B12, and Homocysteine, Cancer Epidemiology Biomarkers & Prevention, 12, 1271
  16. Low, 2002, Folate-mediated delivery of macromolecular anticancer therapeutic agents, Adv Drug Deliv Rev, 54, 675, 10.1016/S0169-409X(02)00042-X · DOI
  17. Kros, 2013, Folic Acid-Modified Mesoporous Silica Nanoparticles for Cellular and Nuclear Targeted Drug Delivery, Advanced Healthcare Materials, 2, 281, 10.1002/adhm.201200176 · DOI
  18. Linden, 2009, Targeting of porous hybrid silica nanoparticles to cancer cells, ACS Nano, 3, 197, 10.1021/nn800781r · DOI
  19. Rosenholm, 2015, Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect, Biomater Sci, 3, 103, 10.1039/C4BM00278D · DOI
  20. El-Serag, 2011, Hepatocellular carcinoma, N Engl J Med, 365, 1118, 10.1056/NEJMra1001683 · DOI · Paper page
  21. Liang, 2009, Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial, Lancet Oncol, 10, 25, 10.1016/S1470-2045(08)70285-7 · DOI · Paper page
  22. Reynolds, 2009, Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy, Clin Cancer Res, 15, 1126, 10.1158/1078-0432.CCR-08-0144 · DOI
  23. Adjei, 2005, Targeting apoptosis pathways in cancer therapy, CA Cancer J Clin, 55, 178, 10.3322/canjclin.55.3.178 · DOI
  24. Kamarul, 2016, Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?, Cell Death & Disease, 7, e2058, 10.1038/cddis.2015.275 · DOI
  25. Wang, 2016, Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms, Oncotarget, 7, 22623, 10.18632/oncotarget.8033 · DOI
  26. Lin, 2016, Mcl-1 as a potential therapeutic target for human hepatocelluar carcinoma, J Huazhong Univ Sci Technolog Med Sci, 36, 494, 10.1007/s11596-016-1614-7 · DOI
  27. Wang, 2015, Sorafenib and DE605, a novel c-Met inhibitor, synergistically suppress hepatocellular carcinoma, Oncotarget, 6, 12340, 10.18632/oncotarget.3656 · DOI
  28. Salganik, 2007, Hydrogen peroxide overproduced in breast cancer cells can serve as an anticancer prodrug generating apoptosis-stimulating hydroxyl radicals under the effect of tamoxifen-ferrocene conjugate, J Pharm Pharmacol, 59, 1549, 10.1211/jpp.59.11.0013 · DOI
  29. Jayakumar, 2014, An update on prodrugs from natural products, Asian Pacific Journal of Tropical Medicine, 7, S54, 10.1016/S1995-7645(14)60203-0 · DOI
  30. Li, 2014, Plant natural products: from traditional compounds to new emerging drugs in cancer therapy, Cell Prolif, 47, 506, 10.1111/cpr.12143 · DOI
  31. Battino, 2015, The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment, Food and Chemical Toxicology, 75, 58, 10.1016/j.fct.2014.11.004 · DOI
  32. Mousa, 2011, Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects, Cancers, 3, 4024, 10.3390/cancers3044024 · DOI
  33. Dhanaraju, 2014, Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine, Asian Pacific Journal of Tropical Biomedicine, 4, S1, 10.12980/APJTB.4.2014C980 · DOI
  34. Xu, 2015, Natural product-based nanomedicine: recent advances and issues, Int J Nanomedicine, 10, 6055, 10.2147/IJN.S92162 · DOI
  35. Gillies, 2014, Curcumin, a promising anti-cancer therapeutic: a review of its chemical properties, bioactivity and approaches to cancer cell delivery, RSC Advances, 4, 10815, 10.1039/c3ra46396f · DOI
  36. Srivatsan, 2011, Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma, Mol Cancer, 10, 12, 10.1186/1476-4598-10-12 · DOI
  37. Burd, 2009, Chapter 27-Quercetin: A Potential Complementary and Alternative Cancer Therapy A2-Watson, Ronald Ross. Complementary and Alternative Therapies and the Aging Population, 563
  38. Cossarizza, 2011, Quercetin and cancer chemoprevention, Evid Based Complement Alternat Med, 2011, 591356, 10.1093/ecam/neq053 · DOI
  39. Schmidt, 2001, Current aspects of colchicine therapy — classical indications and new therapeutic uses, Eur J Med Res, 6, 150
  40. Bartl, 2015, Synthesis, antiproliferative and antibacterial evaluation of C-ring modified colchicine analogues, Eur J Med Chem, 90, 296, 10.1016/j.ejmech.2014.11.037 · DOI
  41. Khedr, 2016, pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles, Journal of Nanomedicine & Nanotechnology, 1
  42. Khedr, 2016, Mesoporous Silica Materials in Drug Delivery System: pH/Glutathione-Responsive Release of Poorly Water-Soluble Pro-drug Quercetin from Two and Three-dimensional Pore-Structure Nanoparticles, Journal of Nanomedicine & Nanotechnology, 1
  43. Tsao, 2011, An overview of the c-MET signaling pathway, Ther Adv Med Oncol, 3, S7, 10.1177/1758834011422556 · DOI
  44. Akgul, 2009, Mcl-1 is a potential therapeutic target in multiple types of cancer, Cell Mol Life Sci, 66, 1326, 10.1007/s00018-008-8637-6 · DOI
  45. Mainardes, 2016, Bovine Serum Albumin Nanoparticles Containing Quercetin: Characterization and Antioxidant Activity, J Nanosci Nanotechnol, 16, 1346, 10.1166/jnn.2016.11672 · DOI
  46. Hu, 2016, Enhancement of curcumin water dispersibility and antioxidant activity using core-shell protein–polysaccharide nanoparticles, Food Research International, 87, 1, 10.1016/j.foodres.2016.06.009 · DOI
  47. Hu, 2017, Resveratrol encapsulation in core-shell biopolymer nanoparticles: Impact on antioxidant and anticancer activities, Food Hydrocolloids, 64, 157, 10.1016/j.foodhyd.2016.10.029 · DOI
  48. Jang, 2014, Synthesis and characterization of pharmaceutical surfactant templated mesoporous silica: Its application to controlled delivery of duloxetine, Materials Research Bulletin, 51, 228, 10.1016/j.materresbull.2013.12.037 · DOI
  49. Gao, 2014, Synthesis of novel core-shell structured dual-mesoporous silica nanospheres and their application for enhancing the dissolution rate of poorly water-soluble drugs, Materials Science and Engineering: C, 44, 262, 10.1016/j.msec.2014.08.040 · DOI
  50. Wang, 2014, Exploitation of 3D face-centered cubic mesoporous silica as a carrier for a poorly water soluble drug: Influence of pore size on release rate, Materials Science and Engineering: C, 34, 78, 10.1016/j.msec.2013.08.014 · DOI
  51. Vallet-Regí, 2006, Controlled release of Ibuprofen from dealuminated faujasites, Solid State Sciences, 8, 1459, 10.1016/j.solidstatesciences.2006.07.016 · DOI
  52. Karmakar, 2014, Effect of surface functionality of silica nanoparticles on cellular uptake and cytotoxicity, Mol Pharm, 11, 3642, 10.1021/mp500385n · DOI
  53. Yuan, 2013, Effects of particle morphology, pore size and surface coating of mesoporous silica on Naproxen dissolution rate enhancement, Colloids and Surfaces B: Biointerfaces, 101, 228, 10.1016/j.colsurfb.2012.06.026 · DOI
  54. Vallet-Regí, 2003, MCM-41 Organic Modification as Drug Delivery Rate Regulator, Chemistry of Materials, 15, 500, 10.1021/cm021217q · DOI
  55. Huang, 2007, The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells, Biomaterials, 28, 2959, 10.1016/j.biomaterials.2007.03.006 · DOI
  56. Yang, 2008, Synthesis and Characterization of Positive-Charge Functionalized Mesoporous Silica Nanoparticles for Oral Drug Delivery of an Anti-Inflammatory Drug, Advanced Functional Materials, 18, 3283, 10.1002/adfm.200800521 · DOI
  57. Oupický, 2012, Surface Functionalization of Mesoporous Silica Nanoparticles Controls Loading and Release Behavior of Mitoxantrone, Pharmaceutical Research, 29, 2407, 10.1007/s11095-012-0766-9 · DOI
  58. Valoti, 2014, Functionalized mesoporous silica nanoparticles for oral delivery of budesonide, Journal of Solid State Chemistry, 211, 154, 10.1016/j.jssc.2013.12.020 · DOI
  59. Luan, 2013, Folate-conjugated hybrid SBA-15 particles for targeted anticancer drug delivery, J Colloid Interface Sci, 395, 31, 10.1016/j.jcis.2012.12.016 · DOI
  60. Wu, 2011, Targeted anticancer prodrug with mesoporous silica nanoparticles as vehicles, Nanotechnology, 22, 455102, 10.1088/0957-4484/22/45/455102 · DOI
  61. Mehraban, 2009, Removal of Ni(II), Cd(II), and Pb(II) from a ternary aqueous solution by amino functionalized mesoporous and nano mesoporous silica, Chemical Engineering Journal, 153, 70, 10.1016/j.cej.2009.06.016 · DOI
  62. Yin, 2014, Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers, ACS Appl Mater Interfaces, 6, 8447, 10.1021/am501337s · DOI
  63. Garcia-Bennett, 2007, Mesoporous silica particles induce size dependent effects on human dendritic cells, Nano Lett, 7, 3576, 10.1021/nl0714785 · DOI
  64. Xu, 2012, Cell-specific intracellular anticancer drug delivery from mesoporous silica nanoparticles with pH sensitivity, Adv Healthc Mater, 1, 321, 10.1002/adhm.201100030 · DOI
  65. Cai, 2013, Engineering a Hollow Nanocontainer Platform with Multifunctional Molecular Machines for Tumor-Targeted Therapyand, ACS Nano, 7, 10271, 10.1021/nn404676w · DOI
  66. Zhao, 2012, Multifunctional Mesoporous Silica Nanoparticles for Cancer-Targeted and Controlled Drug Delivery, Advanced Functional Materials, 22, 5144, 10.1002/adfm.201201316 · DOI
  67. Yang, 2015, A Functionalized Hollow Mesoporous Silica Nanoparticles-Based Controlled Dual-Drug Delivery System for Improved Tumor Cell Cytotoxicity, Particle & Particle Systems Characterization, 32, 222, 10.1002/ppsc.201400115 · DOI
  68. Wu, 2014, Redox responsive Pd(ii) templated rotaxane nanovalve capped mesoporous silica nanoparticles: a folic acid mediated biocompatible cancer-targeted drug delivery system, Journal of Materials Chemistry B, 2, 7009, 10.1039/C4TB01030B · DOI
  69. Abbasi, 2003, Molecular mechanism of apoptosis: prediction of three-dimensional structure of caspase-6 and its interactions by homology modeling, Biochemical and Biophysical Research Communications, 308, 497, 10.1016/S0006-291X(03)01394-9 · DOI
  70. Babaei, 2014, Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells, Int J Nanomedicine, 9, 403
  71. Zhang, 2015, Synthesis, characterization, andevaluation of curcumin-loaded albumin nanoparticles surface-functionalized with glycyrrhetinic acid, Int J Nanomedicine, 10, 5475, 10.2147/IJN.S88253 · DOI
  72. Lopez-Lazaro, 2007, Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy, Cancer Lett, 252, 1, 10.1016/j.canlet.2006.10.029 · DOI
  73. Ma, 2016, Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer, Oxid Med Cell Longev, 2016, 1616781, 10.1155/2016/1616781 · DOI
  74. Wang, 2015, Increased Oxidative Stress as a Selective Anticancer Therapy, Oxid Med Cell Longev, 2015, 294303
  75. Burns, 2005, Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells, Arch Biochem Biophys, 440, 181, 10.1016/j.abb.2005.06.015 · DOI
  76. Nozawa, 2011, Cisplatin induces production of reactive oxygen species via NADPH oxidase activation in human prostate cancer cells, Free Radic Res, 45, 1033, 10.3109/10715762.2011.591391 · DOI
  77. Bruix, 2008, Molecular targeted therapies in hepatocellular carcinoma, Hepatology, 48, 1312, 10.1002/hep.22506 · DOI
  78. Zou, 2016, Curcumin mediates reversion of HGF-induced epithelial-mesenchymal transition via inhibition of c-Met expression in DU145 cells, Oncol Lett, 11, 1499, 10.3892/ol.2015.4063 · DOI
  79. Rountree, 2011, c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma, Hepatology, 54, 879, 10.1002/hep.24450 · DOI
  80. Kim, 2012, The Blocking of c-Met Signaling Induces Apoptosis through the Increase of p53 Protein in Lung Cancer, Cancer Research and Treatment, 44, 251, 10.4143/crt.2012.44.4.251 · DOI
  81. Shore, 2008, Unique biology of Mcl-1: therapeutic opportunities in cancer, Curr Mol Med, 8, 138, 10.2174/156652408783769580 · DOI
  82. Li-Weber, 2011, Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1, Cell Death & Disease, 2, e182, 10.1038/cddis.2011.66 · DOI
  83. Chen, 2002, The experimental and clinical study on the effect of curcumin on cell cycle proteins and regulating proteins of apoptosis in acute myelogenous leukemia, J Huazhong Univ Sci Technolog Med Sci, 22, 295, 10.1007/BF02896768 · DOI
  84. Halliwell, 2007, Biochemistry of oxidative stress, Biochem Soc Trans, 35, 1147, 10.1042/BST0351147 · DOI
  85. Tamanoi, 2012, tumor suppression efficacy of mesoporous silica nanoparticles-based drug-delivery system: enhanced efficacy by folate modification, Nanomedicine, 8, 212, 10.1016/j.nano.2011.06.002 · DOI
  86. Basset, 2010, High-Surface-Area Silica Nanospheres (KCC-1) with a Fibrous Morphology, Angewandte Chemie (International Ed. In English), 49, 9652, 10.1002/anie.201003451 · DOI
  87. Brühwiler, 2010, Influence of the Structural Properties of Mesoporous Silica on the Adsorption of Guest Molecules, Materials, 3, 4500, 10.3390/ma3084500 · DOI
  88. Asefa, 2014, Dendritic Silica Nanomaterials (KCC-1) with Fibrous Pore Structure Possess High DNA Adsorption Capacity and Effectively Deliver Genes, Langmuir, 30, 10886, 10.1021/la501435a · DOI
  89. Hirvonen, 2011, Drug delivery formulations of ordered and nonordered mesoporous silica: comparison of three drug loading methods, J Pharm Sci, 100, 3294, 10.1002/jps.22577 · DOI
  90. Mosmann, 1983, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J Immunol Methods, 65, 55, 10.1016/0022-1759(83)90303-4 · DOI · Paper page
  91. Berset, 1995, Use of a free radical method to evaluate antioxidant activity, LWT - Food Science and Technology, 28, 25, 10.1016/S0023-6438(95)80008-5 · DOI · Paper page
  92. Rice-Evans, 1999, Antioxidant activity applying an improved ABTS radical cation decolorization assay, Free Radic Biol Med, 26, 1231, 10.1016/S0891-5849(98)00315-3 · DOI
  93. Wu, 2014, Rapid publication-ready MS-Word tables for one-way ANOVA, SpringerPlus, 3, 474, 10.1186/2193-1801-3-474 · DOI

Cited by

Sorted by citations

See all 83

Metadata

Authors
AbouAitah, K., Swiderska-Sroda, A., Farghali, A. A., Wojnarowicz, J., Stefanek, A., Gierlotka, S., Opalinska, A., Allayeh, A. K., Ciach, T., & Lojkowski, W.
Affiliations
  • Department of Medicinal and Aromatic Plants Research, Pharmaceutical and Drug Industries Research Division, National Research Centre (NRC), Dokki, Giza, Egypt
  • Laboratory of Nanostructures, Institute of High Pressure Physics, Polish Academy of Sciences, Warsaw, Poland
  • Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt
  • Biomedical Engineering Laboratory, Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warsaw, Poland
  • Environmental Virology Laboratory, National Research Centre (NRC), Dokki, Giza, Egypt
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2018-05-29
Volume
9
Issue
41
Pages
26466-26490
ISSN
1949-2553
DOI
10.18632/oncotarget.25470
PMC
PMC5995188
Cited by
83
References
2
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Folic acid-conjugated mesoporous silica particles as nanocarriers of natural prodrugs for cancer targeting and antioxidant action. https://app.cochat.ai/papers/10.18632/oncotarget.25470
The paper
AbouAitah, K., Swiderska-Sroda, A., Farghali, A. A., Wojnarowicz, J., Stefanek, A., Gierlotka, S., Opalinska, A., Allayeh, A. K., Ciach, T., & Lojkowski, W. (2018). Folic acid-conjugated mesoporous silica particles as nanocarriers of natural prodrugs for cancer targeting and antioxidant action. Oncotarget. https://doi.org/10.18632/oncotarget.25470