The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Bioengineered Bacterial Outer Membrane Vesicles as Cell-Specific Drug-Delivery Vehicles for Cancer Therapy
Abstract
Advances in genetic engineering tools have contributed to the development of strategies for utilizing biologically derived vesicles as nanomedicines for achieving cell-specific drug delivery. Here, we describe bioengineered bacterial outer membrane vesicles (OMVs) with low immunogenicity that can target and kill cancer cells in a cell-specific manner by delivering small interfering RNA (siRNA) targeting kinesin spindle protein (KSP). A mutant Escherichia coli strain that exhibits reduced endotoxicity toward human cells was engineered to generate OMVs displaying a human epidermal growth factor receptor 2 (HER2)-specific affibody in the membrane as a targeting ligand. Systemic injection of siRNA-packaged OMVs caused targeted gene silencing and induced highly significant tumor growth regression in an animal model. Importantly, the modified OMVs were well tolerated and showed no evidence of nonspecific side effects. We propose that bioengineered OMVs have great potential as cell-specific drug-delivery vehicles for treating various cancers.
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Cites
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Cited by
Extracellular vesicles as a next-generation drug delivery platform
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Immune modulation by bacterial outer membrane vesicles
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Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response
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Cell or Cell Membrane-Based Drug Delivery Systems
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Metadata
- Authors
- Gujrati, V., Kim, S., Kim, S.-H., Min, J. J., Choy, H. E., Kim, S. C., & Jon, S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-01-15
- Volume
- 8
- Issue
- 2
- Pages
- 1525-1537
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2049044362
- Cited by
- 543
- References
- 46
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gujrati, V., Kim, S., Kim, S.-H., Min, J. J., Choy, H. E., Kim, S. C., & Jon, S. (2014). Bioengineered Bacterial Outer Membrane Vesicles as Cell-Specific Drug-Delivery Vehicles for Cancer Therapy. ACS Nano. https://doi.org/10.1021/nn405724x
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