The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Diamond Nanogel-Embedded Contact Lenses Mediate Lysozyme-Dependent Therapeutic Release
Open accessAbstract
Temporarily implanted devices, such as drug-loaded contact lenses, are emerging as the preferred treatment method for ocular diseases like glaucoma. Localizing the delivery of glaucoma drugs, such as timolol maleate (TM), can minimize adverse effects caused by systemic administration. Although eye drops and drug-soaked lenses allow for local treatment, their utility is limited by burst release and a lack of sustained therapeutic delivery. Additionally, wet transportation and storage of drug-soaked lenses result in drug loss due to elution from the lenses. Here we present a nanodiamond (ND)-embedded contact lens capable of lysozyme-triggered release of TM for sustained therapy. We find that ND-embedded lenses composed of enzyme-cleavable polymers allow for controlled and sustained release of TM in the presence of lysozyme. Retention of drug activity is verified in primary human trabecular meshwork cells. These results demonstrate the translational potential of an ND-embedded lens capable of drug sequestration and enzyme activation.
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Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
Fluorescent PLLA-nanodiamond composites for bone tissue engineering
Zhang, Q., Mochalin, V. N., Neitzel, I., Knoke, I. Y., Han, J., Klug, C. A., Zhou, J. G., Lelkes, P. I., & Gogotsi, Y. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.090 · Cited by 399
Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus
Ensign, L. M., Tang, B. C., Wang, Y.-Y., Tse, T. A., Hoen, T., Cone, R., & Hanes, J. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003453 · Cited by 368
Cited by
Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects
Begines, B., Ortiz, T., Pérez-Aranda, M., Martínez, G., Merinero, M., Argüelles-Arias, F., & Alcudia, A. (2020) · Nanomaterials · doi:10.3390/nano10071403 · Cited by 1,061
Advances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 855
Yetisen, A. K., Martinez‐Hurtado, J. L., Ünal, B., Khademhosseini, A., & Butt, H. (2018) · Advanced Materials · doi:10.1002/adma.201706910 · Cited by 569
A Hydrogel-Based Hybrid Theranostic Contact Lens for Fungal Keratitis
Huang, J.-F., Zhong, J., Chen, G.-P., Lin, Z.-T., Deng, Y., Liu, Y.-L., Cao, P.-Y., Wang, B., Wei, Y., Wu, T., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b00601 · Cited by 257
Yang, H., Zhang, F., Fan, Y., Zhang, J., Fang, T., Xing, D., Zhen, Y., Nie, Z., Liu, Y., Wang, D., et al. (2024) · Pharmaceutical Research · doi:10.1007/s11095-024-03672-8 · Cited by 14
Metadata
- Authors
- Kim, H.-J., Zhang, K., Moore, L., & Ho, D.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-02-12
- Volume
- 8
- Issue
- 3
- Pages
- 2998-3005
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2053540049
- Cited by
- 220
- References
- 3
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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