Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus
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Mucus-penetrating particles improve drug delivery to the mucosal surface of the mouse vagina and deliver acyclovir for enhanced protection against vaginal herpes infection in mice.
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Acyclovir monophosphate nanoparticles protected ~54% of mice infected with HSV-2 30 min post-treatment, whereas soluble drug protected only 16%.
“Acyclovir monophosphate nanoparticles protected ~54% of the mice that were infected with HSV-2 30 min post-treatment. In contrast, the soluble drug protected only 16% of the mice from viral challenge.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [26]
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- Authors
- Ensign, L. M., Tang, B. C., Wang, Y.-Y., Tse, T. A., Hoen, T., Cone, R., & Hanes, J.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Tang, Benjamin C.
- Hanes, Justin
- Venue
- Science Translational Medicine
- Published
- 2012-06-13
- Volume
- 4
- Issue
- 138
- Pages
- 138ra79-138ra79
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3817739
- OpenAlex
- W2109074171
- Cited by
- 368
- References
- 55
- Citations by year
- 2026: 26 · 2025: 15 · 2024: 28 · 2023: 23 · 2022: 21 · 2021: 36 · 2020: 34 · 2019: 25 · 2018: 20 · 2017: 33 · 2016: 25 · 2015: 25 · 2014: 36 · 2013: 14 · 2012: 6
- FWCI
- 16.05
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (R01CA140746)
- National Institute of Allergy and Infectious Diseases (R33AI094519, R21AI094519, R33AI079740)
- National Institute of Biomedical Imaging and Bioengineering (R21EB008515)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- vaginal drug delivery, herpes simplex virus type 2, mucoadhesion, drug retention, STD prevention, microbicides, nanoparticle aggregation, nanoparticle toxicity
- MeSH terms
- Acyclovir, Administration, Intravaginal, Animals, Female, Humans, Vagina, Simplexvirus, Mice, Nanoparticles
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