Cited by 368Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryAdvancements in Transdermal Drug Delivery

Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus

Open access
Ensign, Laura M., Tang, Benjamin C., Wang, Ying-Ying, Tse, Terence A., Hoen, Timothy, Cone, Richard, Hanes, Justin·2012·Science Translational Medicine

Abstract

Mucus-penetrating particles improve drug delivery to the mucosal surface of the mouse vagina and deliver acyclovir for enhanced protection against vaginal herpes infection in mice.

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Integrity signals

Registry

Crossref · 10.1126/scitranslmed.3003453

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54 of 54 references verified0 citation errors · 0 not checkable

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  • Acyclovir monophosphate nanoparticles protected ~54% of mice infected with HSV-2 30 min post-treatment, whereas soluble drug protected only 16%.

    “Acyclovir monophosphate nanoparticles protected ~54% of the mice that were infected with HSV-2 30 min post-treatment. In contrast, the soluble drug protected only 16% of the mice from viral challenge.”

    From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [26]

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Cites

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1 of the 55 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. [25]Mestecky J OP McGhee JR Lambrecht BN Mucosal Immunology 2005 Elselvier Academic Press Burlington ed. Third
  2. [42]Cu Y Booth CJ Saltzman WM In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery J Control Release 10.1016/j.jconrel.2011.06.036 PMC3220785 21763739 · DOI · Paper page

Cited by

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Authors
Ensign, L. M., Tang, B. C., Wang, Y.-Y., Tse, T. A., Hoen, T., Cone, R., & Hanes, J.
Affiliations
Johns Hopkins University (US)
Corresponding author
  • Tang, Benjamin C.
  • Hanes, Justin
Venue
Science Translational Medicine
Published
2012-06-13
Volume
4
Issue
138
Pages
138ra79-138ra79
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2109074171
Cited by
368
References
55
Citations by year
2026: 26 · 2025: 15 · 2024: 28 · 2023: 23 · 2022: 21 · 2021: 36 · 2020: 34 · 2019: 25 · 2018: 20 · 2017: 33 · 2016: 25 · 2015: 25 · 2014: 36 · 2013: 14 · 2012: 6
FWCI
16.05
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Cancer Institute (R01CA140746)
  • National Institute of Allergy and Infectious Diseases (R33AI094519, R21AI094519, R33AI079740)
  • National Institute of Biomedical Imaging and Bioengineering (R21EB008515)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords
vaginal drug delivery, herpes simplex virus type 2, mucoadhesion, drug retention, STD prevention, microbicides, nanoparticle aggregation, nanoparticle toxicity
MeSH terms
Acyclovir, Administration, Intravaginal, Animals, Female, Humans, Vagina, Simplexvirus, Mice, Nanoparticles

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