The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
DNA Dendrimer: An Efficient Nanocarrier of Functional Nucleic Acids for Intracellular Molecular Sensing
Open accessAbstract
Functional nucleic acid (FNA)-based sensing systems have been developed for efficient detection of a wide range of biorelated analytes by employing DNAzymes or aptamers as recognition units. However, their intracellular delivery has always been a concern, mainly in delivery efficiency, kinetics, and the amount of delivered FNAs. Here we report a DNA dendrimer scaffold as an efficient nanocarrier to deliver FNAs and to conduct in situ monitoring of biological molecules in living cells. A histidine-dependent DNAzyme and an anti-ATP aptamer were chosen separately as the model FNAs to make the FNA dendrimer. The FNA-embedded DNA dendrimers maintained the catalytic activity of the DNAzyme or the aptamer recognition function toward ATP in the cellular environment, with no change in sensitivity or specificity. Moreover, these DNA dendrimeric nanocarriers show excellent biocompatibility, high intracellular delivery efficiency, and sufficient stability in a cellular environment. This FNA dendrimeric nanocarrier may find a broad spectrum of applications in biomedical diagnosis and therapy.
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Cites
Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays
Drmanac, R., Sparks, A. B., Callow, M. J., Halpern, A. L., Burns, N. L., Kermani, B. G., Carnevali, P., Nazarenko, I., Nilsen, G. B., Yeung, G., et al. (2010) · Science · doi:10.1126/science.1181498 · Cited by 1,212
Cited by
DNA Nanotechnology-Enabled Drug Delivery Systems
Hu, Q., Li, H., Wang, L., Gu, H., & Fan, C. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00663 · Cited by 1,118
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
Meng, H.-M., Liu, H., Kuai, H., Peng, R., Mo, L., & Zhang, X.-B. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00645g · Cited by 608
Self-citationDNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications
Dong, Y., Yao, C., Zhu, Y., Yang, L., Luo, D., & Yang, D. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00294 · Cited by 533
Biostable L-DNAzyme for Sensing of Metal Ions in Biological Systems
Cui, L., Peng, R., Fu, T., Zhang, X., Wu, C., Chen, H., Liang, H., Yang, C. J., & Tan, W. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04170 · Cited by 81
Self-citationStatic DNA Nanostructures For Cancer Theranostics: Recent Progress In Design And Applications
Jahanban-Esfahlan, R., Seidi, K., Jahanban-Esfahlan, A., Jaymand, M., Alizadeh, E., Majdi, H., Najjar, R., Javaheri, T., & Zare, P. (2019) · Nanotechnology, Science and Applications · doi:10.2147/nsa.s227193 · Cited by 50
Metadata
- Authors
- Meng, H.-M., Zhang, X., Lv, Y., Zhao, Z., Wang, N.-N., Fu, T., Fan, H., Liang, H., Qiu, L., Zhu, G., & Tan, W.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-05-13
- Volume
- 8
- Issue
- 6
- Pages
- 6171-6181
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2322917738
- Cited by
- 170
- References
- 1
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Meng, H.-M., Zhang, X., Lv, Y., Zhao, Z., Wang, N.-N., Fu, T., Fan, H., Liang, H., Qiu, L., Zhu, G., & Tan, W. (2014). DNA Dendrimer: An Efficient Nanocarrier of Functional Nucleic Acids for Intracellular Molecular Sensing. ACS Nano. https://doi.org/10.1021/nn5015962
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