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Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes
Open accessAbstract
Nanoparticles, including multiwalled carbon nanotubes (MWNTs), strongly absorb near-infrared (nIR) radiation and efficiently convert absorbed energy to released heat which can be used for localized hyperthermia applications. We demonstrate for the first time that DNA-encasement increases heat emission following nIR irradiation of MWNTs, and DNA-encased MWNTs can be used to safely eradicate a tumor mass in vivo. Upon irradiation of DNA-encased MWNTs, heat is generated with a linear dependence on irradiation time and laser power. DNA-encasement resulted in a 3-fold reduction in the concentration of MWNTs required to impart a 10 degrees C temperature increase in bulk solution temperature. A single treatment consisting of intratumoral injection of MWNTs (100 microL of a 500 microg/mL solution) followed by laser irradiation at 1064 nm, 2.5 W/cm(2) completely eradicated PC3 xenograft tumors in 8/8 (100%) of nude mice. Tumors that received only MWNT injection or laser irradiation showed growth rates indistinguishable from nontreated control tumors. Nonmalignant tissues displayed no long-term damage from treatment. The results demonstrate that DNA-encased MWNTs are more efficient at converting nIR irradiation into heat compared to nonencased MWNTs and that DNA-encased MWNTs can be used safely and effectively for the selective thermal ablation of malignant tissue in vivo.
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Cited by
Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy
Robinson, J. T., Tabakman, S. M., Liang, Y., Wang, H., Sanchez Casalongue, H., Vinh, D., & Dai, H. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2010175 · Cited by 2,099
Using Graphene Oxide High Near‐Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease
Li, M., Yang, X., Ren, J., Qu, K., & Qu, X. (2012) · Advanced Materials · doi:10.1002/adma.201104864 · Cited by 535
Liu, X., Tao, H., Yang, K., Zhang, S., Lee, S.-T., & Liu, Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.096 · Cited by 417
Cheng, L., Yang, K., Li, Y., Zeng, X., Shao, M., Lee, S.-T., & Liu, Z. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.069 · Cited by 386
Antaris, A. L., Robinson, J. T., Yaghi, O. K., Hong, G., Diao, S., Luong, R., & Dai, H. (2013) · ACS Nano · doi:10.1021/nn4006472 · Cited by 310
Metadata
- Authors
- Ghosh, S., Dutta, S., Gomes, E., Carroll, D., D’Agostino, R., Olson, J., Guthold, M., & Gmeiner, W. H.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-08-05
- Volume
- 3
- Issue
- 9
- Pages
- 2667-2673
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2144623776
- Cited by
- 260
- References
- 0
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ghosh, S., Dutta, S., Gomes, E., Carroll, D., D’Agostino, R., Olson, J., Guthold, M., & Gmeiner, W. H. (2009). Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes. ACS Nano. https://doi.org/10.1021/nn900368b
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