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Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy

Robinson, Joshua T., Tabakman, Scott M., Liang, Yongye, Wang, Hailiang, Sanchez Casalongue, Hernan, Vinh, Daniel, Dai, Hongjie·2011·Journal of the American Chemical Society

Abstract

We developed nanosized, reduced graphene oxide (nano-rGO) sheets with high near-infrared (NIR) light absorbance and biocompatibility for potential photothermal therapy. The single-layered nano-rGO sheets were ∼20 nm in average lateral dimension, functionalized noncovalently by amphiphilic PEGylated polymer chains to render stability in biological solutions and exhibited 6-fold higher NIR absorption than nonreduced, covalently PEGylated nano-GO. Attaching a targeting peptide bearing the Arg-Gly-Asp (RGD) motif to nano-rGO afforded selective cellular uptake in U87MG cancer cells and highly effective photoablation of cells in vitro. In the absence of any NIR irradiation, nano-rGO exhibited little toxicity in vitro at concentrations well above the doses needed for photothermal heating. This work established nano-rGO as a novel photothermal agent due to its small size, high photothermal efficiency, and low cost as compared to other NIR photothermal agents including gold nanomaterials and carbon nanotubes.

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Metadata

Authors
Robinson, J. T., Tabakman, S. M., Liang, Y., Wang, H., Sanchez Casalongue, H., Vinh, D., & Dai, H.
Venue
Journal of the American Chemical Society
Published
2011-04-08
Volume
133
Issue
17
Pages
6825-6831
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2326443463
Cited by
2,099
References
2
FWCI
63.08
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy. https://app.cochat.ai/papers/10.1021/ja2010175
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Robinson, J. T., Tabakman, S. M., Liang, Y., Wang, H., Sanchez Casalongue, H., Vinh, D., & Dai, H. (2011). Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy. Journal of the American Chemical Society. https://doi.org/10.1021/ja2010175

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