The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nano-flares for mRNA Regulation and Detection
Open accessAbstract
We build off the previously described concept of a nanoflare to develop an oligonucleotide gold nanoparticle conjugate that is capable of both detecting and regulating intracellular levels of mRNA. We characterize the binding rate and specificity of these materials using survivin, a gene associated with the diagnosis and treatment of cancer, as a target. The nanoconjugate enters cells and binds mRNA, thereby decreasing the relative abundance of mRNA in a dose- and sequence-dependent manner, resulting in a fluorescent response. This represents the first demonstration of a single material capable of both mRNA regulation and detection. Further, we investigate the intracellular biochemistry of the nanoconjugate, elucidating its mechanism of gene regulation. This work is important to the study of biologically active nanomaterials such as the nanoflare and is a first step toward the development of an mRNA responsive "theranostic".
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Progress in antisense technology
Crooke, S. T. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.55.091902.104408 · Cited by 417 · cited 2×
“In previous work using similar nanoconjugates, we observed depletion in protein levels,(45) which can be caused by either translation inhibition or mRNA depletion.(37) Here, we find that nanoconjugates deplete mRNA, a phenomenon that has been observed with traditional antisense oligonucleotides.”
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Cited by
Gold Nanoparticles for Biology and Medicine
Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C., & Mirkin, C. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200904359 · Cited by 2,356
Self-citationCutler, J. I., Auyeung, E., & Mirkin, C. A. (2012) · Journal of the American Chemical Society · doi:10.1021/ja209351u · Cited by 1,119
Self-citationRatiometric optical nanoprobes enable accurate molecular detection and imaging
Huang, X., Song, J., Yung, B. C., Huang, X., Xiong, Y., & Chen, X. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00612h · Cited by 820
DNA nanotechnology from the test tube to the cell
Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594
Metadata
- Authors
- Prigodich, A. E., Seferos, D. S., Massich, M. D., Giljohann, D. A., Lane, B. C., & Mirkin, C. A.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-07-13
- Volume
- 3
- Issue
- 8
- Pages
- 2147-2152
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2049628338
- Cited by
- 284
- References
- 1
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- green
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