The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Polymer-Functionalized Nanodiamond Platforms as Vehicles for Gene Delivery
Abstract
Gene therapy holds great promise for treating diseases ranging from inherited disorders to acquired conditions and cancers. Nonetheless, because a method of gene delivery that is both effective and safe has remained elusive, these successes were limited. Functional nanodiamonds (NDs) are rapidly emerging as promising carriers for next-generation therapeutics with demonstrated potential. Here we introduce NDs as vectors for in vitro gene delivery via surface-immobilization with 800 Da polyethyleneimine (PEI800) and covalent conjugation with amine groups. We designed PEI800-modified NDs exhibiting the high transfection efficiency of high molecular weight PEI (PEI25K), but without the high cytotoxicity inherent to PEI25K. Additionally, we demonstrated that the enhanced delivery properties were exclusively mediated by the hybrid ND-PEI800 material and not exhibited by any of the materials alone. This platform approach represents an efficient avenue toward gene delivery via DNA-functionalized NDs, and serves as a rapid, scalable, and broadly applicable gene therapy strategy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., & Behr, J. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,247
The use of nanocrystals in biological detection
Alivisatos, P. (2004) · Nature Biotechnology · doi:10.1038/nbt927 · Cited by 3,008
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
Nanoscale imaging magnetometry with diamond spins under ambient conditions
Balasubramanian, G., Chan, I. Y., Kolesov, R., Al-Hmoud, M., Tisler, J., Shin, C., Kim, C., Wojcik, A., Hemmer, P. R., Krueger, A., et al. (2008) · Nature · doi:10.1038/nature07278 · Cited by 1,999
Ultralong spin coherence time in isotopically engineered diamond
Balasubramanian, G., Neumann, P., Twitchen, D., Markham, M., Kolesov, R., Mizuochi, N., Isoya, J., Achard, J., Beck, J., Tissler, J., et al. (2009) · Nature Materials · doi:10.1038/nmat2420 · Cited by 1,936
Nanoshell-Enabled Photothermal Cancer Therapy: Impending Clinical Impact
Lal, S., Clare, S. E., & Halas, N. J. (2008) · Accounts of Chemical Research · doi:10.1021/ar800150g · Cited by 1,625
Quantum Dots as Cellular Probes
Alivisatos, A. P., Gu, W., & Larabell, C. (2005) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.7.060804.100432 · Cited by 1,366
Drug Delivery with Carbon Nanotubes for In vivo Cancer Treatment
Liu, Z., Chen, K., Davis, C., Sherlock, S., Cao, Q., Chen, X., & Dai, H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1468 · Cited by 1,348
Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis
Akinc, A., Thomas, M., Klibanov, A. M., & Langer, R. (2005) · The Journal of Gene Medicine · doi:10.1002/jgm.696 · Cited by 1,337
Cited by
The properties and applications of nanodiamonds
Mochalin, V. N., Shenderova, O., Ho, D., & Gogotsi, Y. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2011.209 · Cited by 2,745
Self-citationAharonovich, I., Greentree, A. D., & Prawer, S. (2011) · Nature Photonics · doi:10.1038/nphoton.2011.54 · Cited by 631
Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Ashfold, M. N. R., Goss, J. P., Green, B. L., May, P. W., Newton, M. E., & Peaker, C. V. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00518 · Cited by 284
Cheng, L.-C., Chen, H. M., Lai, T.-C., Chan, Y.-C., Liu, R.-S., Sung, J. C., Hsiao, M., Chen, C.-H., Her, L.-J., & Tsai, D. P. (2013) · Nanoscale · doi:10.1039/c3nr34091k · Cited by 63
Metadata
- Authors
- Zhang, X.-Q., Chen, M., Lam, R., Xu, X., Osawa, E., & Ho, D.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-08-31
- Volume
- 3
- Issue
- 9
- Pages
- 2609-2616
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1986218064
- Cited by
- 395
- References
- 44
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Polymer-Functionalized Nanodiamond Platforms as Vehicles for Gene Delivery. https://app.cochat.ai/papers/10.1021/nn900865g
- The paper
- Zhang, X.-Q., Chen, M., Lam, R., Xu, X., Osawa, E., & Ho, D. (2009). Polymer-Functionalized Nanodiamond Platforms as Vehicles for Gene Delivery. ACS Nano. https://doi.org/10.1021/nn900865g
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
